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EJNMMI Research
Published in: EJNMMI Research 1/2018

Open Access 01-12-2018 | Short communication

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Authors: Emma E. Wolters, Sandeep S. V. Golla, Tessa Timmers, Rik Ossenkoppele, Chris W. J. van der Weijden, Philip Scheltens, Lothar Schwarte, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Maqsood Yaqub, Adriaan A. Lammertsma, Ronald Boellaard, Bart N. M. van Berckel

Published in: EJNMMI Research | Issue 1/2018

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Abstract

Background

Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC).

Methods

PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used.

Results

For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05).

Conclusion

PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.
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Metadata
Title
A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus
Authors
Emma E. Wolters
Sandeep S. V. Golla
Tessa Timmers
Rik Ossenkoppele
Chris W. J. van der Weijden
Philip Scheltens
Lothar Schwarte
Robert C. Schuit
Albert D. Windhorst
Frederik Barkhof
Maqsood Yaqub
Adriaan A. Lammertsma
Ronald Boellaard
Bart N. M. van Berckel
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2018
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-018-0432-2

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