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Open Access 01-12-2017 | Original research

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

Authors: Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin, Andrea Varrone

Published in: EJNMMI Research | Issue 1/2017

Abstract

Background

Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study, we seek to revisit the well-established Logan plot and derive alternative formulations that provide estimation of distribution volume ratios (DVRs) that are corrected for the signal originating from the vasculature.

Results

New expressions for the Logan plot based on arterial input function and reference tissue were derived, which included explicit terms for whole blood radioactivity. The new methods were evaluated using PET data acquired using [¹¹C]raclopride and [¹⁸F]MNI-659. The two-tissue compartment model (2TCM), with which signal originating from blood can be explicitly modeled, was used as a gold standard.

DVR values obtained for [¹¹C]raclopride using the either blood-based or reference tissue-based Logan plot were systematically underestimated compared to 2TCM, and for [¹⁸F]MNI-659, a proportionality bias was observed, i.e., the bias varied across regions. The biases disappeared when optimal blood-signal correction was used for respective tracer, although for the case of [¹⁸F]MNI-659 a small but systematic overestimation of DVR was still observed.

Conclusions

The new method appears to remove the bias introduced due to absence of correction for blood volume in regular graphical analysis and can be considered in clinical studies. Further studies are however required to derive a generic mapping between plasma and whole-blood radioactivity levels.

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Title: Revisiting the Logan plot to account for non-negligible blood volume in brain tissue
Authors: Martin Schain
Patrik Fazio
Ladislav Mrzljak
Nahid Amini
Nabil Al-Tawil
Cheryl Fitzer-Attas
Juliana Bronzova
Bernhard Landwehrmeyer
Christina Sampaio
Christer Halldin
Andrea Varrone
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2017
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/s13550-017-0314-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

Abstract

Background

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Results

Conclusions

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