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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2023

Open Access 01-12-2023 | Hypospadia | Case report

Male refractory hypospadias with sexual reversal: a case report

Authors: Jianfeng Zhao, Gang Chen, Jun Chen, Le Qian

Published in: Journal of Medical Case Reports | Issue 1/2023

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Abstract

Background

Hypospadias is one of the most prevalent urogenital malformations in clinic. However, some hypospadias may have a more complex disorder of sex development. Usually, hypospadias in these patients is severe. Among them, the 46,XX male sex reversal syndrome is a rare disorder of sex development, and this may be the main reason for this type of hypospadias being difficult to repair.

Case presentation

We present a Han nationality 19-year-old male with failure of repeated repair of hypospadias. No sperm was found on semen analysis. Lingual mucosal graft was carried out for this patient. It still did not succeed after using lingual mucosal graft repair. Karyotype analysis of this patient confirmed 46,XX karyotype.

Conclusion

Hypospadias with 46,XX male sex reversal syndrome is hard to repair. Chromosome karyotype examination in patients with hypospadias is suggested. Genetic testing is recommended. In the future, further research is needed on the pathogenesis of disease and how to treat and prevent it.
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Metadata
Title
Male refractory hypospadias with sexual reversal: a case report
Authors
Jianfeng Zhao
Gang Chen
Jun Chen
Le Qian
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2023
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-023-04230-3

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