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Published in: Journal of Medical Case Reports 1/2022

Open Access 01-12-2022 | Human Papillomavirus | Case report

Condyloma acuminatum of the urinary bladder with underlying squamous cell carcinoma: a case report

Author: John A. Whitaker

Published in: Journal of Medical Case Reports | Issue 1/2022

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Abstract

Background

Condyloma acuminatum is a rare finding of the urinary bladder. There are many morphological variants that exist. It has been previously reported that some of these variants were found to be associated with subsequent or concurrent squamous cell carcinoma. However, there are limited cases that describe this underlying malignancy found in patients with bladder condyloma.

Case presentation

A 38-year-old African American female presented with condyloma acuminatum of the urinary bladder and underlying squamous cell carcinoma, which also invaded the neighboring uterus, urethra, and anterior vagina. Initial attempts at treatment began with cystoscopic resection of the condyloma; however, due to diffuse transformation, we pursued radical cystectomy with adjuvant chemotherapy and radiation.

Conclusion

As such a finding is rare in the urinary bladder, with few reports discussing its association with ensuing squamous cell carcinoma, we hope that this continues to generate awareness and consideration in the treatment of affected individuals.
Literature
1.
go back to reference Meliti A, Hawari A, Al-Maghrabi H, Mokhtar G. Condyloma accuminatum of the male urethra: a case report. SAGE Open Med Case Rep [Internet]. 2020;8:2050313X2090458. Meliti A, Hawari A, Al-Maghrabi H, Mokhtar G. Condyloma accuminatum of the male urethra: a case report. SAGE Open Med Case Rep [Internet]. 2020;8:2050313X2090458.
2.
go back to reference Gormley RH, Kovarik CL. Human papillomavirus-related genital disease in the immunocompromised host: part I. J Am Acad Dermatol [Internet]. 2012;66(6):867.e1-867.e14.PubMed Gormley RH, Kovarik CL. Human papillomavirus-related genital disease in the immunocompromised host: part I. J Am Acad Dermatol [Internet]. 2012;66(6):867.e1-867.e14.PubMed
3.
go back to reference Camargo CC de, Tasca KI, Mendes MB, Miot HA, Souza L do R de. Prevalence of anogenital warts in men with HIV/AIDS and associated factors. Open AIDS J [Internet]. 2014 Oct 2 [cited 2022 Sep 5];8(1):25. Available from: /pmc/articles/PMC4195172/ Camargo CC de, Tasca KI, Mendes MB, Miot HA, Souza L do R de. Prevalence of anogenital warts in men with HIV/AIDS and associated factors. Open AIDS J [Internet]. 2014 Oct 2 [cited 2022 Sep 5];8(1):25. Available from: /pmc/articles/PMC4195172/
4.
go back to reference Guo CC, Fine SW, Epstein JI. Noninvasive squamous lesions in the urinary bladder: a clinicopathologic analysis of 29 cases. Am J Surg Pathol [Internet]. 2006;30(7):883–91.CrossRefPubMed Guo CC, Fine SW, Epstein JI. Noninvasive squamous lesions in the urinary bladder: a clinicopathologic analysis of 29 cases. Am J Surg Pathol [Internet]. 2006;30(7):883–91.CrossRefPubMed
5.
go back to reference Samarska IV, Epstein JI. Condyloma acuminatum of urinary bladder: relation to squamous cell carcinoma. Am J Surg Pathol [Internet]. 2019;43(11):1547–53.CrossRefPubMed Samarska IV, Epstein JI. Condyloma acuminatum of urinary bladder: relation to squamous cell carcinoma. Am J Surg Pathol [Internet]. 2019;43(11):1547–53.CrossRefPubMed
6.
go back to reference Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol [Internet]. 2003;44(6):672–81.CrossRefPubMed Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol [Internet]. 2003;44(6):672–81.CrossRefPubMed
7.
go back to reference El-Bolkainy MN, Mokhtar NM, Ghoneim MA, Hussein MH. The impact of schistosomiasis on the pathology of bladder carcinoma. El-Bolkainy MN, Mokhtar NM, Ghoneim MA, Hussein MH. The impact of schistosomiasis on the pathology of bladder carcinoma.
8.
go back to reference Cumberbatch MG, Rota M, Catto JWF, la Vecchia C. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol [Internet]. 2016;70(3):458–66.CrossRefPubMed Cumberbatch MG, Rota M, Catto JWF, la Vecchia C. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol [Internet]. 2016;70(3):458–66.CrossRefPubMed
9.
go back to reference Freedman ND, Silverman DT, Hollenbeck AR, Schatzkin A, Abnet CC. Association between smoking and risk of bladder cancer among men and women. JAMA [Internet]. 2011;306(7):737–45.CrossRefPubMedPubMedCentral Freedman ND, Silverman DT, Hollenbeck AR, Schatzkin A, Abnet CC. Association between smoking and risk of bladder cancer among men and women. JAMA [Internet]. 2011;306(7):737–45.CrossRefPubMedPubMedCentral
10.
go back to reference Nordenvall C, Chang ET, Adami HO, Ye W. Cancer risk among patients with condylomata acuminata. Int J Cancer [Internet]. 2006;119(4):888–93.CrossRefPubMed Nordenvall C, Chang ET, Adami HO, Ye W. Cancer risk among patients with condylomata acuminata. Int J Cancer [Internet]. 2006;119(4):888–93.CrossRefPubMed
11.
go back to reference Wiley DJ, Off DE, Masongsong EV, Harper DM, Gylys KH, Silverberg MJ, et al. Smoking enhances risk for new external genital warts in men. Int J Environ Res Public Health [Internet]. 2009;6(3):1215.CrossRefPubMedPubMedCentral Wiley DJ, Off DE, Masongsong EV, Harper DM, Gylys KH, Silverberg MJ, et al. Smoking enhances risk for new external genital warts in men. Int J Environ Res Public Health [Internet]. 2009;6(3):1215.CrossRefPubMedPubMedCentral
12.
go back to reference Kaderli R, Schnüriger B, Brügger LE. The impact of smoking on HPV infection and the development of anogenital warts. Int J Colorectal Dis [Internet]. 2014;29(8):899–908.CrossRefPubMed Kaderli R, Schnüriger B, Brügger LE. The impact of smoking on HPV infection and the development of anogenital warts. Int J Colorectal Dis [Internet]. 2014;29(8):899–908.CrossRefPubMed
13.
go back to reference Sarier M, Ozel E, Duman I, Yuksel Y, Demirbas A. HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. Transpl Infect Dis [Internet]. 2017;19(2). Sarier M, Ozel E, Duman I, Yuksel Y, Demirbas A. HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. Transpl Infect Dis [Internet]. 2017;19(2).
14.
go back to reference Zayko MO, Velilla RE, Shurbaji MS. Condyloma acuminata presenting as isolated papillary lesions in the prostatic urethra. Am J Case Rep [Internet]. 2018;19:1522.CrossRefPubMedPubMedCentral Zayko MO, Velilla RE, Shurbaji MS. Condyloma acuminata presenting as isolated papillary lesions in the prostatic urethra. Am J Case Rep [Internet]. 2018;19:1522.CrossRefPubMedPubMedCentral
15.
go back to reference Jablonska S. Traditional therapies for the treatment of condylomata acuminata (genital warts). Australas J Dermatol [Internet]. 1998;39(Suppl 1):S2-4.PubMed Jablonska S. Traditional therapies for the treatment of condylomata acuminata (genital warts). Australas J Dermatol [Internet]. 1998;39(Suppl 1):S2-4.PubMed
16.
go back to reference Batta AG, Engen DE, Reiman HM, Winkelmann RK. Intravesical condyloma acuminatum with progression to verrucous carcinoma. Urology [Internet]. 1990;36(5):457–64.CrossRefPubMed Batta AG, Engen DE, Reiman HM, Winkelmann RK. Intravesical condyloma acuminatum with progression to verrucous carcinoma. Urology [Internet]. 1990;36(5):457–64.CrossRefPubMed
17.
go back to reference White R, Donnellan S, Leong T. Complete resolution of urinary bladder condyloma acuminatum following definitive chemoradiotherapy for anal cancer. BJU Int [Internet]. 2011;108(SUPPL2):38–41.CrossRefPubMed White R, Donnellan S, Leong T. Complete resolution of urinary bladder condyloma acuminatum following definitive chemoradiotherapy for anal cancer. BJU Int [Internet]. 2011;108(SUPPL2):38–41.CrossRefPubMed
18.
go back to reference Richie JP, Waisman J, Skinner DG, Dretler SP. Squamous carcinoma of the bladder: treatment by radical cystectomy. J Urol [Internet]. 1976;115(6):670–2.CrossRefPubMed Richie JP, Waisman J, Skinner DG, Dretler SP. Squamous carcinoma of the bladder: treatment by radical cystectomy. J Urol [Internet]. 1976;115(6):670–2.CrossRefPubMed
19.
go back to reference Rundle JSH, Hart AJL, McGeorge A, Smith JS, Malcolm AJ, Smith PM. Squamous cell carcinoma of bladder. A review of 114 patients. Br J Urol. 1982;54(5):522–6.CrossRefPubMed Rundle JSH, Hart AJL, McGeorge A, Smith JS, Malcolm AJ, Smith PM. Squamous cell carcinoma of bladder. A review of 114 patients. Br J Urol. 1982;54(5):522–6.CrossRefPubMed
20.
go back to reference Scosyrev E, Yao J, Messing E. Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology [Internet]. 2009;73(4):822–7.CrossRefPubMed Scosyrev E, Yao J, Messing E. Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology [Internet]. 2009;73(4):822–7.CrossRefPubMed
21.
go back to reference Baumann BC, Zaghloul MS, Sargos P, Murthy V. Adjuvant and neoadjuvant radiation therapy for locally advanced bladder cancer. Clin Oncol R Coll Radiol [Internet]. 2021;33(6):391–9.CrossRefPubMed Baumann BC, Zaghloul MS, Sargos P, Murthy V. Adjuvant and neoadjuvant radiation therapy for locally advanced bladder cancer. Clin Oncol R Coll Radiol [Internet]. 2021;33(6):391–9.CrossRefPubMed
22.
go back to reference Nishiyama H, Habuchi T, Watanabe J, Teramukai S, Tada H, Ono Y, et al. Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990–2000 in Japan. Eur Urol [Internet]. 2004;45(2):176–81.CrossRefPubMed Nishiyama H, Habuchi T, Watanabe J, Teramukai S, Tada H, Ono Y, et al. Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990–2000 in Japan. Eur Urol [Internet]. 2004;45(2):176–81.CrossRefPubMed
Metadata
Title
Condyloma acuminatum of the urinary bladder with underlying squamous cell carcinoma: a case report
Author
John A. Whitaker
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2022
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-022-03669-0

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