Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2022

Open Access 01-12-2022 | Insulins | Case report

Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report

Authors: Yasaman Sharifi, Mahbube Ebrahimpur, Seyed Saeed Tamehrizadeh

Published in: Journal of Medical Case Reports | Issue 1/2022

Login to get access

Abstract

Background

Hypoglycemia is a fairly common complication in diabetic patients, particularly in those on insulin therapy. Hypoglycemia symptoms are classified into two types: autonomic and neuroglycopenic symptoms. If a person develops neuroglycopenic symptoms before the appearance of autonomic symptoms or is asymptomatic until blood sugar levels are very low, the patient will develop hypoglycemic unawareness (HU).

Case presentation

A 25-year-old Iranian woman with HU presented with a severe hypoglycemic episode. This episode was characterized by loss of consciousness and focal neural deficits, which were unusual symptoms in the patient, who was a medical intern with type 1 diabetes and currently being treated with regular and NPH insulin.

Conclusions

Hypoglycemia is a common complication in diabetic patients receiving oral or insulin therapy. A patient who is unaware of their condition may experience severe and potentially fatal episodes. These incidents can negatively affect their daily lives as well as their careers and jobs. Hypoglycemia-associated autonomic failure is a possible cause for patients with multiple episodes of severe hypoglycemia. IThe use of a continuous glucose monitoring device with an alarm, if available, can be an excellent option for these patients.
Literature
1.
go back to reference Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care. 2003;26(6):1902–12.CrossRef Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care. 2003;26(6):1902–12.CrossRef
2.
go back to reference Cryer PE. Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinol Metab Clin North Am. 1999;28(3):495–500.CrossRef Cryer PE. Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinol Metab Clin North Am. 1999;28(3):495–500.CrossRef
3.
go back to reference Hoeldtke RD, Boden G. Epinephrine secretion, hypoglycemia unawareness, and diabetic autonomic neuropathy. Ann Intern Med. 1994;120(6):512–7.CrossRef Hoeldtke RD, Boden G. Epinephrine secretion, hypoglycemia unawareness, and diabetic autonomic neuropathy. Ann Intern Med. 1994;120(6):512–7.CrossRef
4.
go back to reference Greenspan SL, Resnick MN. Geriatric endocrinology. In: Greenspan FS, Strewler GJ, editors. Basic and clinical endocrinology. 7th ed. Stamford: Appleton and Lange; 1997. Greenspan SL, Resnick MN. Geriatric endocrinology. In: Greenspan FS, Strewler GJ, editors. Basic and clinical endocrinology. 7th ed. Stamford: Appleton and Lange; 1997.
5.
go back to reference Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, et al. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol-Endocrinol Metabol. 1991;260(1):E67–74.CrossRef Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, et al. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol-Endocrinol Metabol. 1991;260(1):E67–74.CrossRef
6.
go back to reference Wilson JD, Foster DW, Kronenberg HM, Larsen PR. The anterior pituitary. Williams textbook of endocrinology. 9th ed. Philadelphia: WB Saunders Co; 1998. p. 250–326. Wilson JD, Foster DW, Kronenberg HM, Larsen PR. The anterior pituitary. Williams textbook of endocrinology. 9th ed. Philadelphia: WB Saunders Co; 1998. p. 250–326.
7.
go back to reference Joslin EP, Kahn CR. Joslin’s Diabetes Mellitus: Edited by C. Ronald Kahn...[et al.]. 2005: Lippincott Williams & Wilkins. Joslin EP, Kahn CR. Joslin’s Diabetes Mellitus: Edited by C. Ronald Kahn...[et al.]. 2005: Lippincott Williams & Wilkins.
8.
go back to reference Cryer PE. Hypoglycemia: pathophysiology, diagnosis, and treatment. Oxford:: Oxford University Press; 1997. Cryer PE. Hypoglycemia: pathophysiology, diagnosis, and treatment. Oxford:: Oxford University Press; 1997.
9.
go back to reference Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes. 1993;42(9):1233–7.CrossRef Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes. 1993;42(9):1233–7.CrossRef
10.
go back to reference Kalra S, Mukherjee JJ, Venkataraman S, Bantwal G, Shaikh S, Saboo B, et al. Hypoglycemia: the neglected complication. Indian J Endocrinol Metabol. 2013;17(5):819–34.CrossRef Kalra S, Mukherjee JJ, Venkataraman S, Bantwal G, Shaikh S, Saboo B, et al. Hypoglycemia: the neglected complication. Indian J Endocrinol Metabol. 2013;17(5):819–34.CrossRef
11.
go back to reference Cryer P. Hypoglycemia in diabetes: pathophysiology, prevalence, and prevention. Arlington County: American Diabetes Association; 2016. Cryer P. Hypoglycemia in diabetes: pathophysiology, prevalence, and prevention. Arlington County: American Diabetes Association; 2016.
12.
go back to reference Cryer PE. Hypoglycemia. In: Loriaux L, Vanek C, editors. Endocrine emergencies: recognition and treatment. Cham: Springer International Publishing; 2021. p. 27–35.CrossRef Cryer PE. Hypoglycemia. In: Loriaux L, Vanek C, editors. Endocrine emergencies: recognition and treatment. Cham: Springer International Publishing; 2021. p. 27–35.CrossRef
13.
go back to reference Liu J, Wang R, Ganz ML, Paprocki Y, Schneider D, Weatherall J. The burden of severe hypoglycemia in type 1 diabetes. Curr Med Res Opin. 2018;34(1):171–7.CrossRef Liu J, Wang R, Ganz ML, Paprocki Y, Schneider D, Weatherall J. The burden of severe hypoglycemia in type 1 diabetes. Curr Med Res Opin. 2018;34(1):171–7.CrossRef
14.
go back to reference Whipple AO. Thesurgical therapy of hyperinsu-linism. J Int Chir. 1938;3:237–76. Whipple AO. Thesurgical therapy of hyperinsu-linism. J Int Chir. 1938;3:237–76.
15.
go back to reference American Diabetes Association. 6. Glycemic targets: standards of medical care in diabetes—2020. Diabetes Care. 2020;43(Suppl 1):S66. American Diabetes Association. 6. Glycemic targets: standards of medical care in diabetes—2020. Diabetes Care. 2020;43(Suppl 1):S66.
16.
go back to reference Lamounier RN, Geloneze B, Leite SO, Montenegro R, Zajdenverg L, Fernandes M, et al. Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil. Diabetol Metab Syndr. 2018;10(1):1–10.CrossRef Lamounier RN, Geloneze B, Leite SO, Montenegro R, Zajdenverg L, Fernandes M, et al. Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil. Diabetol Metab Syndr. 2018;10(1):1–10.CrossRef
17.
go back to reference Amiel SA, Choudhary P, Jacob P, Smith EL, De Zoysa N, Gonder-Frederick L, et al. Hypoglycaemia awareness restoration programme for people with type 1 diabetes and problematic hypoglycaemia persisting despite optimised self-care (HARPdoc): protocol for a group randomised controlled trial of a novel intervention addressing cognitions. BMJ Open. 2019;9(6):e030356.CrossRef Amiel SA, Choudhary P, Jacob P, Smith EL, De Zoysa N, Gonder-Frederick L, et al. Hypoglycaemia awareness restoration programme for people with type 1 diabetes and problematic hypoglycaemia persisting despite optimised self-care (HARPdoc): protocol for a group randomised controlled trial of a novel intervention addressing cognitions. BMJ Open. 2019;9(6):e030356.CrossRef
18.
go back to reference Hopkins D, Lawrence IA, Mansell P, Thompson G, Amiel S, Campbell M, et al. Improved biomedical and psychological outcomes 1 year after structured education in flexible insulin therapy for people with type 1 diabetes: the UK DAFNE experience. Diabetes Care. 2012;35(8):1638–42.CrossRef Hopkins D, Lawrence IA, Mansell P, Thompson G, Amiel S, Campbell M, et al. Improved biomedical and psychological outcomes 1 year after structured education in flexible insulin therapy for people with type 1 diabetes: the UK DAFNE experience. Diabetes Care. 2012;35(8):1638–42.CrossRef
19.
go back to reference Binder C, Bendtson I. Endocrine emergencies. Hypoglycaemia. Bailliere’s Clin Endocrinol Metabol. 1992;6(1):23–39.CrossRef Binder C, Bendtson I. Endocrine emergencies. Hypoglycaemia. Bailliere’s Clin Endocrinol Metabol. 1992;6(1):23–39.CrossRef
20.
go back to reference Pedersen-Bjergaard U, Pramming S, Heller SR, Wallace TM, Rasmussen ÅK, Jørgensen HV, et al. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev. 2004;20(6):479–86.CrossRef Pedersen-Bjergaard U, Pramming S, Heller SR, Wallace TM, Rasmussen ÅK, Jørgensen HV, et al. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev. 2004;20(6):479–86.CrossRef
21.
go back to reference Zammitt NN, Geddes J, Warren RE, Marioni R, Ashby JP, Frier BM. Serum angiotensin-converting enzyme and frequency of severe hypoglycaemia in Type 1 diabetes: does a relationship exist? Diabet Med. 2007;24(12):1449–54.CrossRef Zammitt NN, Geddes J, Warren RE, Marioni R, Ashby JP, Frier BM. Serum angiotensin-converting enzyme and frequency of severe hypoglycaemia in Type 1 diabetes: does a relationship exist? Diabet Med. 2007;24(12):1449–54.CrossRef
22.
go back to reference McCulloch D. Physiologic response to hypoglycemia in normal subjects and patients with diabetes mellitus. Up to Date (Medical), 1998. McCulloch D. Physiologic response to hypoglycemia in normal subjects and patients with diabetes mellitus. Up to Date (Medical), 1998.
23.
go back to reference Becker K. Endocrine drugs and values. Principles and practice of endocrinology and metabolism. Philadelphia: JB Lippincott; 1990. Becker K. Endocrine drugs and values. Principles and practice of endocrinology and metabolism. Philadelphia: JB Lippincott; 1990.
24.
go back to reference [No authors listed]. Hypoglycemia in the diabetes control and complications trial. Diabetes. 1997;46(2):271–86. [No authors listed]. Hypoglycemia in the diabetes control and complications trial. Diabetes. 1997;46(2):271–86.
25.
go back to reference Diamond MP, Reece EA, Caprio S, Jones TW, Amiel S, DeGennaro N, et al. Impairment of counterregulatory hormone responses to hypoglycemia in pregnant women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol. 1992;166(1):70–7.CrossRef Diamond MP, Reece EA, Caprio S, Jones TW, Amiel S, DeGennaro N, et al. Impairment of counterregulatory hormone responses to hypoglycemia in pregnant women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol. 1992;166(1):70–7.CrossRef
26.
go back to reference Nakhjavani M, Esteghamati A, Emami F, Hoseinzadeh M. Iran J Endocrinol Metabol. 2000;2(1):49–61. Nakhjavani M, Esteghamati A, Emami F, Hoseinzadeh M. Iran J Endocrinol Metabol. 2000;2(1):49–61.
27.
go back to reference Holleman F, Schmitt H, Rottiers R, Rees A, Symanowski S, Anderson JH, et al. Reduced frequency of severe hypoglycemia and coma in well-controlled IDDM patients treated with insulin lispro. Diabetes Care. 1997;20(12):1827–32. Holleman F, Schmitt H, Rottiers R, Rees A, Symanowski S, Anderson JH, et al. Reduced frequency of severe hypoglycemia and coma in well-controlled IDDM patients treated with insulin lispro. Diabetes Care. 1997;20(12):1827–32.
28.
go back to reference Brunelle RL, Llewelyn J, Anderson JH Jr, Gale EA, Koivisto VA. Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes. Diabetes Care. 1998;21(10):1726–31.CrossRef Brunelle RL, Llewelyn J, Anderson JH Jr, Gale EA, Koivisto VA. Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes. Diabetes Care. 1998;21(10):1726–31.CrossRef
29.
go back to reference Anderson JH Jr, Brunelle RL, Koivisto VA, Pfützner A, Trautmann ME, Vignati L, et al. Reduction of postprandial hyperglycemia and frequency of hypoglycemia in IDDM patients on insulin-analog treatment. Diabetes. 1997;46(2):265–70.CrossRef Anderson JH Jr, Brunelle RL, Koivisto VA, Pfützner A, Trautmann ME, Vignati L, et al. Reduction of postprandial hyperglycemia and frequency of hypoglycemia in IDDM patients on insulin-analog treatment. Diabetes. 1997;46(2):265–70.CrossRef
30.
go back to reference Monami M, Marchionni N, Mannucci E. Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. 2008;81(2):184–9.CrossRef Monami M, Marchionni N, Mannucci E. Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. 2008;81(2):184–9.CrossRef
31.
go back to reference Smith CB, Choudhary P, Pernet A, Hopkins D, Amiel SA. Hypoglycemia unawareness is associated with reduced adherence to therapeutic decisions in patients with type 1 diabetes: evidence from a clinical audit. Diabetes Care. 2009;32(7):1196–8.CrossRef Smith CB, Choudhary P, Pernet A, Hopkins D, Amiel SA. Hypoglycemia unawareness is associated with reduced adherence to therapeutic decisions in patients with type 1 diabetes: evidence from a clinical audit. Diabetes Care. 2009;32(7):1196–8.CrossRef
32.
go back to reference Cranston I, Lomas J, Amiel SA, Maran A, Macdonald I. Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet. 1994;344(8918):283–7.CrossRef Cranston I, Lomas J, Amiel SA, Maran A, Macdonald I. Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet. 1994;344(8918):283–7.CrossRef
33.
go back to reference Battelino T, et al. Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes. Diabetes Care. 2011;34(4):795–800.CrossRef Battelino T, et al. Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes. Diabetes Care. 2011;34(4):795–800.CrossRef
34.
go back to reference Wolpert HA. Use of continuous glucose monitoring in the detection and prevention of hypoglycemia. J Diabetes Sci Technol. 2007;1(1):146–50.CrossRef Wolpert HA. Use of continuous glucose monitoring in the detection and prevention of hypoglycemia. J Diabetes Sci Technol. 2007;1(1):146–50.CrossRef
35.
go back to reference Fritsche A, Stumvoll M, Häring HU, Gerich JE. Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of β-adrenergic sensitivity after prevention of hypoglycemia. J Clin Endocrinol Metab. 2000;85(2):523–5. Fritsche A, Stumvoll M, Häring HU, Gerich JE. Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of β-adrenergic sensitivity after prevention of hypoglycemia. J Clin Endocrinol Metab. 2000;85(2):523–5.
36.
go back to reference Cryer PE. Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metabol. 2001;281(6):E1115–21.CrossRef Cryer PE. Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metabol. 2001;281(6):E1115–21.CrossRef
37.
go back to reference Fanelli CG, et al. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes. 1993;42(11):1683–9.CrossRef Fanelli CG, et al. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes. 1993;42(11):1683–9.CrossRef
38.
go back to reference Dagogo-Jack S, Rattarasarn C, Cryer PE. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes. 1994;43(12):1426–34.CrossRef Dagogo-Jack S, Rattarasarn C, Cryer PE. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes. 1994;43(12):1426–34.CrossRef
Metadata
Title
Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report
Authors
Yasaman Sharifi
Mahbube Ebrahimpur
Seyed Saeed Tamehrizadeh
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2022
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-022-03498-1

Other articles of this Issue 1/2022

Journal of Medical Case Reports 1/2022 Go to the issue