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Published in: Journal of Medical Case Reports 1/2022

Open Access 01-12-2022 | Hypocalcemia | Case report

Iatrogenic calcinosis cutis in 9-month-old baby boy: a case report

Authors: Eman Ahmed Alghaith, Ghada Abdullah AlQahtani, Jamal Ahmed Omer

Published in: Journal of Medical Case Reports | Issue 1/2022

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Abstract

Background

Calcinosis cutis is a rare condition, characterized by an accumulation of calcium salts in the skin and subcutaneous tissue. There are several types of this condition, including dystrophic, metastatic, idiopathic, calciphylaxis, and iatrogenic calcinosis cutis. The type related to our case is iatrogenic calcinosis cutis, and one its possible causes is calcium intravenous infusion. Physicians should be aware of this condition when giving calcium infusion.

Case presentation

Here we report the case of a 9-month-old Arabic - Saudi baby boy, who presented with abnormal movement for 1 day. Upon further investigation, his abnormal movement was found to be a manifestation of hypocalcemia and vitamin D deficiency. He was treated with intravenous calcium gluconate. Later, he had a treatment-related complication of intravenous calcium at the site of venipuncture causing swelling, which was initially soft but progressed to hard, over the left hand. Eventually, he was diagnosed with a case of iatrogenic calcinosis cutis due to intravenous calcium treatment.

Conclusion

There are multiple differential diagnoses of calcinosis cutis, as it resembles many other conditions. Careful history-taking, physical examination, and other investigations, such as radiological investigations, will aid in reaching a more accurate diagnosis and, thus, early treatment and intervention. Frequently checking the intravenous line and diluting the intravenous calcium may help reduce the occurrence of iatrogenic calcinosis cutis.
Literature
1.
go back to reference Le C, Bedocs PM. Calcinosis cutis. Treasure Island: Statpearls; 2020. Le C, Bedocs PM. Calcinosis cutis. Treasure Island: Statpearls; 2020.
2.
go back to reference Alsaif F, Abduljabbar AM. Unilateral idiopathic calcinosis cutis: a case report. Case Rep Dermatol. 2017;9:20–4.CrossRef Alsaif F, Abduljabbar AM. Unilateral idiopathic calcinosis cutis: a case report. Case Rep Dermatol. 2017;9:20–4.CrossRef
3.
go back to reference García-García E, López-López R, Álvarez-del-Vayo C, Bernabeu-Wittel J. Iatrogenic calcinosis cutis successfully treated with topical sodium thiosulfate. Pediatr Dermatol. 2017;34:356–8.CrossRef García-García E, López-López R, Álvarez-del-Vayo C, Bernabeu-Wittel J. Iatrogenic calcinosis cutis successfully treated with topical sodium thiosulfate. Pediatr Dermatol. 2017;34:356–8.CrossRef
4.
go back to reference Sawke GK, Rai T, Sawke N. Iatrogenic calcinosis cutis: a rare cytological diagnosis. J Cytol. 2016;33:166–8.CrossRef Sawke GK, Rai T, Sawke N. Iatrogenic calcinosis cutis: a rare cytological diagnosis. J Cytol. 2016;33:166–8.CrossRef
5.
go back to reference Róbert L, Kiss N, Medvecz M, Kuroli E, Sárdy M, Hidvégi B. Epidemiology and treatment of calcinosis cutis: 13 years of experience. Indian J Dermatol. 2020;65(2):105–11.CrossRef Róbert L, Kiss N, Medvecz M, Kuroli E, Sárdy M, Hidvégi B. Epidemiology and treatment of calcinosis cutis: 13 years of experience. Indian J Dermatol. 2020;65(2):105–11.CrossRef
6.
go back to reference Shmidt E, Murthy NS, Knudsen JM, Weenig RH, Jacobs MA, Starnes AM, et al. Net-like pattern of calcification on plain soft-tissue radiographs in patients with calciphylaxis. J Am Acad Dermatol. 2012;67:1296-1301.e2.CrossRef Shmidt E, Murthy NS, Knudsen JM, Weenig RH, Jacobs MA, Starnes AM, et al. Net-like pattern of calcification on plain soft-tissue radiographs in patients with calciphylaxis. J Am Acad Dermatol. 2012;67:1296-1301.e2.CrossRef
7.
go back to reference Meher BK, Mishra P, Sivaraj P, Padhan P. Severe calcinosis cutis with cutaneous ulceration in juvenile dermatomyositis. Indian Pediatr. 2014;51:925–7.CrossRef Meher BK, Mishra P, Sivaraj P, Padhan P. Severe calcinosis cutis with cutaneous ulceration in juvenile dermatomyositis. Indian Pediatr. 2014;51:925–7.CrossRef
8.
go back to reference Balin SJ, Wetter DA, Andersen LK, Davis MDP. Calcinosis cutis occurring in association with autoimmune connective tissue disease: the Mayo Clinic experience with 78 patients, 1996–2009. Arch Dermatol. 2012;148:455–62.CrossRef Balin SJ, Wetter DA, Andersen LK, Davis MDP. Calcinosis cutis occurring in association with autoimmune connective tissue disease: the Mayo Clinic experience with 78 patients, 1996–2009. Arch Dermatol. 2012;148:455–62.CrossRef
9.
go back to reference Leung YY, Lai R. Tumoral calcinosis: a case report. J Orthop Surg (Hong Kong). 2011;19:108–12.CrossRef Leung YY, Lai R. Tumoral calcinosis: a case report. J Orthop Surg (Hong Kong). 2011;19:108–12.CrossRef
10.
go back to reference Arora A, Agarwal A, Kumar S, Gupta SK. Iatrogenic calcinosis cutis—a rare differential diagnosis of soft-tissue infection in a neonate: a case report. J Orthop Surg (Hong Kong). 2005;13:195–8.CrossRef Arora A, Agarwal A, Kumar S, Gupta SK. Iatrogenic calcinosis cutis—a rare differential diagnosis of soft-tissue infection in a neonate: a case report. J Orthop Surg (Hong Kong). 2005;13:195–8.CrossRef
11.
go back to reference Moss J, Syrengelas A, Antaya R, Lazova R. Calcinosis cutis: a complication of intravenous administration of calcium glucanate. J Cutan Pathol. 2006;33:60–2.CrossRef Moss J, Syrengelas A, Antaya R, Lazova R. Calcinosis cutis: a complication of intravenous administration of calcium glucanate. J Cutan Pathol. 2006;33:60–2.CrossRef
12.
go back to reference Bulatovic A, Schlieper G, Stankovic-Popovic V, Vujic D, Floege J, Dimkovic N. Iatrogenic calcinosis cutis after subcutaneous LMW-heparin administration in a hemodialysis patient. Int Urol Nephrol. 2013;45:1239–41.CrossRef Bulatovic A, Schlieper G, Stankovic-Popovic V, Vujic D, Floege J, Dimkovic N. Iatrogenic calcinosis cutis after subcutaneous LMW-heparin administration in a hemodialysis patient. Int Urol Nephrol. 2013;45:1239–41.CrossRef
13.
go back to reference Raffaella C, Annapaola C, Tullio I, Angelo R, Giuseppe L, Simone C. Successful treatment of severe iatrogenic calcinosis cutis with intravenous sodium thiosulfate in a child affected by T-acute lymphoblastic leukemia. Pediatr Dermatol. 2009;26:311–5.CrossRef Raffaella C, Annapaola C, Tullio I, Angelo R, Giuseppe L, Simone C. Successful treatment of severe iatrogenic calcinosis cutis with intravenous sodium thiosulfate in a child affected by T-acute lymphoblastic leukemia. Pediatr Dermatol. 2009;26:311–5.CrossRef
14.
go back to reference Puvabanditsin S, Garrow E, Titapiwatanakun R, Getachew R, Patel JB. Severe calcinosis cutis in an infant. Pediatr Radiol. 2005;35(5):539–42.CrossRef Puvabanditsin S, Garrow E, Titapiwatanakun R, Getachew R, Patel JB. Severe calcinosis cutis in an infant. Pediatr Radiol. 2005;35(5):539–42.CrossRef
15.
go back to reference Rumancik BE, Rahnama-Moghadam S. Severe iatrogenic calcinosis cutis from extravasated calcium gluconate. Cureus. 2020;12:e9712.PubMedPubMedCentral Rumancik BE, Rahnama-Moghadam S. Severe iatrogenic calcinosis cutis from extravasated calcium gluconate. Cureus. 2020;12:e9712.PubMedPubMedCentral
Metadata
Title
Iatrogenic calcinosis cutis in 9-month-old baby boy: a case report
Authors
Eman Ahmed Alghaith
Ghada Abdullah AlQahtani
Jamal Ahmed Omer
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Hypocalcemia
Published in
Journal of Medical Case Reports / Issue 1/2022
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-022-03306-w

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