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Published in: Journal of Medical Case Reports 1/2021

Open Access 01-12-2021 | Cerebral Sinus Venous Thrombosis | Case report

Idiopathic intracranial hypertension presenting as iron deficiency anemia: a case report

Authors: Peng Yong Sim, Priyal Taribagil, Ione O. C. Woollacott, Safina Rashid, Desmond P. Kidd

Published in: Journal of Medical Case Reports | Issue 1/2021

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Abstract

Background

The presentation of idiopathic intracranial hypertension (IIH) in association with iron deficiency anemia (IDA) is rare.

Case presentation

This case report depicts the unusual case of a 31-year-old woman of mixed Jamaican and English heritage with IIH who presented initially as IDA in the context of menorrhagia. Subsequent ophthalmic review, lumbar puncture, cerebrospinal fluid analysis and neuroimaging studies revealed severe bilateral optic disc swelling and raised intracranial pressure in keeping with IIH. Prompt treatment of IDA with blood transfusion and orally administered iron supplements, in addition to medical treatment for IIH, contributed to significant improvement of symptoms and prevented long-term visual deficits.

Conclusion

The possibility of IDA, albeit rare, should always be considered and investigated appropriately in all patients with IIH, as the treatment of the anemia alone may be sight-saving.
Literature
1.
go back to reference Markey KA, Mollan SP, Jensen RH, Sinclair AJ. Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol. 2016;15(1):78–91.CrossRef Markey KA, Mollan SP, Jensen RH, Sinclair AJ. Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol. 2016;15(1):78–91.CrossRef
2.
go back to reference Acheson JF. Idiopathic intracranial hypertension and visual function. Br Med Bull. 2006;79–80(1):233–44.CrossRef Acheson JF. Idiopathic intracranial hypertension and visual function. Br Med Bull. 2006;79–80(1):233–44.CrossRef
3.
go back to reference Capriles LF. Intracranial hypertension and iron-deficiency anemia: report of four cases. Arch Neurol. 1963;9(2):147–53.CrossRef Capriles LF. Intracranial hypertension and iron-deficiency anemia: report of four cases. Arch Neurol. 1963;9(2):147–53.CrossRef
4.
go back to reference Biousse V, Rucker JC, Vignal C, Crassard I, Katz BJ, Newman NJ. Anemia and papilledema. Am J Ophthalmol. 2003;135(4):437–46.CrossRef Biousse V, Rucker JC, Vignal C, Crassard I, Katz BJ, Newman NJ. Anemia and papilledema. Am J Ophthalmol. 2003;135(4):437–46.CrossRef
5.
go back to reference Stoebner R, Kiser R, Alperin JB. Iron deficiency anemia and papilledema. Rapid resolution with oral iron therapy. Am J Dig Dis. 1970;15(10):919–22.CrossRef Stoebner R, Kiser R, Alperin JB. Iron deficiency anemia and papilledema. Rapid resolution with oral iron therapy. Am J Dig Dis. 1970;15(10):919–22.CrossRef
6.
go back to reference Mollan SP, Ball AK, Sinclair AJ, Madill SA, Clarke CE, Jacks AS, et al. Idiopathic intracranial hypertension associated with iron deficiency anaemia: a lesson for management. Eur Neurol. 2009;62(2):105–8.CrossRef Mollan SP, Ball AK, Sinclair AJ, Madill SA, Clarke CE, Jacks AS, et al. Idiopathic intracranial hypertension associated with iron deficiency anaemia: a lesson for management. Eur Neurol. 2009;62(2):105–8.CrossRef
7.
go back to reference Mangat SS. Papilledema due to iron-deficiency anaemia. Philipp J Ophthalmol. 2010;35(2):76–8. Mangat SS. Papilledema due to iron-deficiency anaemia. Philipp J Ophthalmol. 2010;35(2):76–8.
8.
go back to reference Kaul B, Ramanarayanan S, Mahapatra H, Sethi TK, Ahlawat R. Iron deficiency masquerading as idiopathic intracranial hypertension. BMJ Case Rep. 2009;bcr06.2008.0346. Kaul B, Ramanarayanan S, Mahapatra H, Sethi TK, Ahlawat R. Iron deficiency masquerading as idiopathic intracranial hypertension. BMJ Case Rep. 2009;bcr06.2008.0346.
9.
go back to reference Forman EB, O’Byrne JJ, Capra L, McElnea E, King MD. Idiopathic intracranial hypertension associated with iron-deficiency anaemia. Arch Dis Child. 2013;98(6):418.CrossRef Forman EB, O’Byrne JJ, Capra L, McElnea E, King MD. Idiopathic intracranial hypertension associated with iron-deficiency anaemia. Arch Dis Child. 2013;98(6):418.CrossRef
10.
go back to reference Meng C, Lai CT, Jing Y, Jiang HQ, Sun HL, Ma ZH, et al. Clinical analysis of 36 cases of idiopathic intracranial hypertension complicated with iron deficiency anemia. Natl Med J China. 2019;99(33):2592–6. Meng C, Lai CT, Jing Y, Jiang HQ, Sun HL, Ma ZH, et al. Clinical analysis of 36 cases of idiopathic intracranial hypertension complicated with iron deficiency anemia. Natl Med J China. 2019;99(33):2592–6.
11.
go back to reference Johnson-Wimbley TD, Graham DY. Diagnosis and management of iron deficiency anemia in the 21st century. Therap Adv Gastroenterol. 2011;4(3):177–84.CrossRef Johnson-Wimbley TD, Graham DY. Diagnosis and management of iron deficiency anemia in the 21st century. Therap Adv Gastroenterol. 2011;4(3):177–84.CrossRef
12.
go back to reference Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypertension. Neurology. 2002;59(10):1492–5.CrossRef Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypertension. Neurology. 2002;59(10):1492–5.CrossRef
13.
go back to reference Giuseffi V, Wall M, Siegel PZ, Rojas PB. Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology. 1991;41(2):239–44.CrossRef Giuseffi V, Wall M, Siegel PZ, Rojas PB. Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology. 1991;41(2):239–44.CrossRef
14.
go back to reference Wall M, George D. Idiopathic intracranial hypertension. A prospective study of 50 patients. Brain. 1991;114:155–80.CrossRef Wall M, George D. Idiopathic intracranial hypertension. A prospective study of 50 patients. Brain. 1991;114:155–80.CrossRef
15.
go back to reference Ireland B, Corbett JJ, Wallace RB. The search for causes of idiopathic intracranial hypertension. A preliminary case-control study. Arch Neurol. 1990;47(3):315–20.CrossRef Ireland B, Corbett JJ, Wallace RB. The search for causes of idiopathic intracranial hypertension. A preliminary case-control study. Arch Neurol. 1990;47(3):315–20.CrossRef
16.
go back to reference Ardissino M, Moussa O, Tang A, Muttoni E, Ziprin P, Purkayastha S. Idiopathic intracranial hypertension in the British population with obesity. Acta Neurochir (Wien). 2019;161(2):239–46.CrossRef Ardissino M, Moussa O, Tang A, Muttoni E, Ziprin P, Purkayastha S. Idiopathic intracranial hypertension in the British population with obesity. Acta Neurochir (Wien). 2019;161(2):239–46.CrossRef
17.
go back to reference Knizley HJ, Noyes WD. Iron deficiency anemia, papilledema, thrombocytosis, and transient hemiparesis. Arch Intern Med. 1972;129(3):483–6.CrossRef Knizley HJ, Noyes WD. Iron deficiency anemia, papilledema, thrombocytosis, and transient hemiparesis. Arch Intern Med. 1972;129(3):483–6.CrossRef
18.
go back to reference Belman AL, Roque CT, Ancona R, Anand AK, Davis RP. Cerebral venous thrombosis in a child with iron deficiency anemia and thrombocytosis. Stroke. 1990;21(3):488–93.CrossRef Belman AL, Roque CT, Ancona R, Anand AK, Davis RP. Cerebral venous thrombosis in a child with iron deficiency anemia and thrombocytosis. Stroke. 1990;21(3):488–93.CrossRef
19.
go back to reference Hartfield DS, Lowry NJ, Keene DL, Yager JY. Iron deficiency: a cause of stroke in infants and children. Pediatr Neurol. 1997;16(1):50–3.CrossRef Hartfield DS, Lowry NJ, Keene DL, Yager JY. Iron deficiency: a cause of stroke in infants and children. Pediatr Neurol. 1997;16(1):50–3.CrossRef
20.
go back to reference Kuku I, Kaya E, Yologlu S, Gokdeniz R, Baydin A. Platelet counts in adults with iron deficiency anemia. Platelets. 2009;20(6):401–5.CrossRef Kuku I, Kaya E, Yologlu S, Gokdeniz R, Baydin A. Platelet counts in adults with iron deficiency anemia. Platelets. 2009;20(6):401–5.CrossRef
21.
go back to reference Dan K. Thrombocytosis in iron deficiency anemia. Intern Med. 2005;44(10):1025–6.CrossRef Dan K. Thrombocytosis in iron deficiency anemia. Intern Med. 2005;44(10):1025–6.CrossRef
Metadata
Title
Idiopathic intracranial hypertension presenting as iron deficiency anemia: a case report
Authors
Peng Yong Sim
Priyal Taribagil
Ione O. C. Woollacott
Safina Rashid
Desmond P. Kidd
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-020-02631-2

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