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Open Access 01-12-2019 | Magnetic Resonance Imaging | Case report

Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report

Authors: Chieko Miyazaki, Mikio Shiozawa, Rintaro Koike, Kasumi Ogihara, Yumiko Sasaki, Satomi Shiba, Saki Nishida, Masako Sakuragi, Hirofumi Mizunuma, Takashi Fujita, Noriyoshi Fukushima, Alan K. Lefor, Joji Kitayama, Naohiro Sata

Published in: Journal of Medical Case Reports | Issue 1/2019

Abstract

Background

Primary sarcoma of the breast is rare. Surgery has been the only curative treatment available. Recently, neoadjuvant chemotherapy including anthracycline/ifosfamide has been reported effective for patients with high-risk sarcomas in a prospective trial.

Case presentation

A 52-year-old Japanese woman presented with a mass in her left breast. The 10 cm tumor was fixed to her chest wall on examination. A skin biopsy was performed which showed leiomyosarcoma. Neoadjuvant chemotherapy was given and the tumor became mobile. A mastectomy and axillary dissection were performed with surgically negative margins. After neoadjuvant chemotherapy, the amount of necrosis was profoundly influenced by chemotherapy, and the histological effect of neoadjuvant chemotherapy was assessed in reference to pre-neoadjuvant chemotherapy magnetic resonance imaging.

Conclusion

In contrast to many other cancers, the evaluation of various treatments and of the histological effect of neoadjuvant chemotherapy for sarcoma has been difficult due to the rarity of these tumors. We report the case of a patient with a breast sarcoma, treated with neoadjuvant chemotherapy and discuss the appropriate pathological evaluation and therapeutic management.

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Title: Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report
Authors: Chieko Miyazaki
Mikio Shiozawa
Rintaro Koike
Kasumi Ogihara
Yumiko Sasaki
Satomi Shiba
Saki Nishida
Masako Sakuragi
Hirofumi Mizunuma
Takashi Fujita
Noriyoshi Fukushima
Alan K. Lefor
Joji Kitayama
Naohiro Sata
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Soft Tissue Sarcoma
Sarcoma
Cytostatic Therapy
Published in: Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-019-2197-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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