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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2019

Open Access 01-12-2019 | Human Papillomavirus | Case report

Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate: a case report

Authors: Jeremie D. Oliver, Neil S. Patel, Dale C. Ekbom, Janalee K. Stokken

Published in: Journal of Medical Case Reports | Issue 1/2019

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Abstract

Background

Recurrent respiratory papillomatosis is a chronic disease of viral origin affecting the larynx, trachea, and lower airways. Inverted papilloma, most commonly originating from the lateral nasal wall, is typically a single, expansile, locally aggressive tumor that remodels bone around the site of origin.

Case presentation

We report a case of histopathologically proven inverted papilloma occurring in a 50-year-old Caucasian man with recurrent respiratory papillomatosis affecting his nasal cavity, larynx, and trachea. This constitutes the first report of nasal involvement in recurrent respiratory papillomatosis. Viral in situ hybridization studies demonstrated evidence of human papillomavirus in both the septum and middle turbinate subsites. Repeat nasal excision with margin analysis is planned.

Conclusions

This report emphasizes the importance of considering a broad differential diagnosis in patients with papillomata, and obtaining comprehensive histopathologic evaluation of lesions in multiple subsites in order to rule out inverted papilloma or overt malignant transformation, particularly if high-risk human papillomavirus (HPV) subtypes are identified.

Level of evidence

4
Literature
1.
Kashima H, Mounts P, Leventhal B, et al. Sites of predilection in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 1993;102(8):580–3.CrossRef
2.
Taliercio S, Cespedes M, Born H, et al. Adult-onset recurrent respiratory papillomatosis: a review of disease pathogenesis and implications for patient counseling. JAMA Otolaryngol Head Neck Surg. 2015;141(1):78–83.CrossRef
3.
Tatar EÇ, Kupfer RA, Barry JY, et al. Office-based vs traditional operating room Management of Recurrent Respiratory Papillomatosis: impact of patient characteristics and disease severity. JAMA Otolaryngol Head Neck Surg. 2017;143(1):55–9.CrossRef
4.
Karatayli-Ozgursoy S, Bishop JA, Hillel A, et al. Risk factors for dysplasia in recurrent respiratory papillomatosis in an adult and pediatric population. Ann Otol Rhinol Laryngol. 2016;125(3):235–41.CrossRef
5.
Bleier BS, Gawthrop CS, Thaler ER, et al. Diffuse intranasal papillomatosis and its association with human papillomavirus. Arch Otolaryngol Head Neck Surg. 2008;134(7):778–80.CrossRef
6.
Baumann JL, Cohen S, Evjen AN, et al. Human papillomavirus in early laryngeal carcinoma. Laryngoscope. 2009;119(8):1531–7.CrossRef
7.
Hoffmann M, Klose N, Gottschlich S, et al. Detection of human papillomavirus DNA in benign and malignant sinonasal neoplasms. Cancer. 2006;239:64–70.
8.
Govindaraj S, Wang H. Does human papilloma virus play a role in sinonasal inverted papilloma? Curr Opin Otolaryngol Head Neck Surg. 2014;22(1):47–51.CrossRef
9.
Nudell J, Chiosea S, Thompson LD. Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature. Head Neck Pathol. 2014;8(3):269–86.CrossRef
10.
Peng P, Har-El G. Management of inverted papillomas of the nose and paranasal sinuses. Am J Otolaryngol. 2006;27:233–7.CrossRef
Metadata
Title
Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate: a case report
Authors
Jeremie D. Oliver
Neil S. Patel
Dale C. Ekbom
Janalee K. Stokken
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-019-2153-1

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