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Open Access 01-12-2019 | Metastasis | Case report

Persistent response to vemurafenib in metastatic ameloblastoma with BRAF mutation: a case report

Authors: Morgane Broudic-Guibert, Jean-Yves Blay, Léa Vazquez, Alexandre Evrard, Marie Karanian, Sophie Taïeb, Natalie Hoog-Labouret, Céline Mahier Ait Oukhatar, Rania Boustany-Grenier, Antoine Arnaud

Published in: Journal of Medical Case Reports | Issue 1/2019

Abstract

Background

Ameloblastomas are uncommon locally aggressive tumors of odontogenic epithelium that rarely metastasize. Currently, there is no standard of care for the metastatic forms. Several studies have shown that ameloblastomas frequently have a BRAF mutation.

Case presentation

We report a case of a 33-year-old Caucasian woman with ameloblastoma diagnosed 30 years ago who developed lung metastasis 19 years ago. Systemic oral treatment with vemurafenib, a BRAF inhibitor, was initiated 28 months ago within the AcSé French basket clinical trial of vemurafenib.

Conclusions

The patient has shown a durable clinical, functional, and radiographic partial response with vemurafenib. These observations suggest the possibility of introducing neoadjuvant and/or adjuvant targeted therapy in locally advanced ameloblastoma to improve outcome. BRAF inhibition has proved to be an efficient strategy in patients with a BRAF-mutated ameloblastoma.

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Title: Persistent response to vemurafenib in metastatic ameloblastoma with BRAF mutation: a case report
Authors: Morgane Broudic-Guibert
Jean-Yves Blay
Léa Vazquez
Alexandre Evrard
Marie Karanian
Sophie Taïeb
Natalie Hoog-Labouret
Céline Mahier Ait Oukhatar
Rania Boustany-Grenier
Antoine Arnaud
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Metastasis
Pulmonary Nodule
Ameloblastoma
Ameloblastoma
Published in: Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-019-2140-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Persistent response to vemurafenib in metastatic ameloblastoma with BRAF mutation: a case report

Abstract

Background

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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