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Journal of Medical Case Reports

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Open Access 01-12-2018 | Case report

Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

Authors: Sarah Byberg, Bo Abrahamsen, Moustapha Kassem, Stuart Ralston, Peter Schwarz

Published in: Journal of Medical Case Reports | Issue 1/2018

Abstract

Background

A 20-year-old Danish woman with melorheostosis in her right femoral shaft and disabling pain in the affected area, whose symptoms did not in the long term respond to zoledronic acid, experienced continuous remission of pain after treatment with denosumab. To the best of our knowledge, this is the first case report on denosumab treatment for melorheostosis.

Case presentation

Radiologic findings and bone biopsy showed irregular cortical hyperostosis in the right femoral shaft with increased tracer uptake on Tc⁹⁹-bone scan.

The diagnosis of melorheostosis was made based on the radiological findings. There was a good initial response to zoledronic acid administration, but after relapse of pain, the second and third administrations had a poor effect. As a second line of treatment denosumab was administered at 8-week intervals, the frequency was based on our patient’s symptoms and on biochemical markers of bone turnover.

Conclusion

This is the first report indicating that denosumab has a place in the treatment of melorheostosis when the effect of bisphosphonate treatment is insufficient.

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Title: Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report
Authors: Sarah Byberg
Bo Abrahamsen
Moustapha Kassem
Stuart Ralston
Peter Schwarz
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2018
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-018-1820-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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