Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2018

Open Access 01-12-2018 | Case report

Monoclonal gammopathy in prostate carcinoma: a case report and review of literature

Authors: Samik Pramanik, Md Jahangir Gazi, Anjan Kumar Das, Nirod Baran Debnath, Salil K Pal

Published in: Journal of Medical Case Reports | Issue 1/2018

Login to get access

Abstract

Background

Monoclonal gammopathy is commonly associated with plasma cell dyscrasia. However, monoclonal gammopathy without bone marrow plasmacytosis in prostate carcinoma has rarely been reported. The association between the two conditions is not clearly established.

Case presentation

We report a case of metastatic prostate carcinoma in a 65-year-old Indian man with the unusual phenomenon of monoclonal band in gamma globulin region without evidence of bone marrow plasmacytosis.

Conclusions

Monoclonal gammopathy in solid tumor has seldom been reported. This case report highlights the rare association of monoclonal gammopathy with malignant prostatic carcinoma. Therefore, while investigating a case such as this, in an elderly male patient, we should always keep a lookout for any solid tumor foci after excluding multiple myeloma.
Literature
1.
Kyle RA. Current concepts on monoclonal gammopathies. Aust NZ J Med. 1992;22:291.CrossRef
2.
Talerman A, Hije WG. The frequency of M-components in sera of patients with solid malignant neoplasms. Br J Cancer. 1973;27:276.CrossRef
3.
Sehgal T, Sharma S, Naseem S, Varma N, Das A, Sharma SC. Synchronous Occurrence of Prostate Carcinoma and Multiple Myeloma: A Case Report. Indian J Hematol Blood Transfus. 2014;30(Suppl 1):359–62.CrossRef
4.
Huang E, Teh BS, Saleem A, Butler EB. Recurrence of prostate adenocarcinoma presenting with multiple myeloma simulating skeletal metastases of prostate adenocarcinoma. Urology. 2002;60(6):1111.CrossRef
5.
Kao J, Jani AB, Vijayakumar S. Is there an association between multiple myeloma and prostate cancer? Med Hypotheses. 2004;63(2):226–31.CrossRef
6.
Niels WC, et al. The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network. Haematologica. 2014;99(6):984–96.CrossRef
7.
Abdul M, Hoosein NM. Gammopathy associated with advanced prostate carcinoma. Urol Res. 1995;23(3):185–8.CrossRef
8.
Migliore PJ, Alexanian R. Monoclonal gammopathy in human neoplasia. Cancer. 1968;21(6):1127–31.CrossRef
9.
Solomon A. Homogeneous (monoclonal) immunoglobulins in cancer. Am J Med. 1977;63(2):169–76.CrossRef
10.
lsobe T, Osserman EF. Pathologic conditions associated with plasma cell dyscrasias: a study of 806 cases. Ann N Y Acad Sci. 1971;190:507.CrossRef
11.
Hellström KE, Hellström I. Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv lmmunol. 1974;18:209.CrossRef
Metadata
Title
Monoclonal gammopathy in prostate carcinoma: a case report and review of literature
Authors
Samik Pramanik
Md Jahangir Gazi
Anjan Kumar Das
Nirod Baran Debnath
Salil K Pal
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2018
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-018-1811-z

Other articles of this Issue 1/2018

Journal of Medical Case Reports 1/2018 Go to the issue

Case report

Purpura induced by laser hair removal: a case report

Case report

Deep vein thrombosis and pulmonary embolism secondary to urinary retention: a case report

Case report

Tuberculous sacroiliitis with secondary psoas abscess in an older patient: a case report

Case report

Novel variant of reversed midgut rotation – retro-arterial proximal jejunum and transverse colon: a case report and review of the literature

Case report

The use of a skin-stretching device combined with vacuum sealing drainage for closure of a large skin defect: a case report

Case report

Rapid bupropion-induced hepatotoxicity: a case report and review of the literature