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Open Access 01-12-2018 | Case report

Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports

Authors: Toyonobu Tsuda, Hayato Tada, Yoshihiro Tanaka, Naoto Nishida, Taiji Yoshida, Takeshi Sawada, Kenji Sakata, Kenshi Hayashi, Masa-aki Kawashiri, Takeru Oyama, Motoko Sasaki, Nozomu Kurose, Masakazu Yamagishi

Published in: Journal of Medical Case Reports | Issue 1/2018

Abstract

Background

Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury.

Case presentation

We report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone.

Conclusions

We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected.

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Title: Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
Authors: Toyonobu Tsuda
Hayato Tada
Yoshihiro Tanaka
Naoto Nishida
Taiji Yoshida
Takeshi Sawada
Kenji Sakata
Kenshi Hayashi
Masa-aki Kawashiri
Takeru Oyama
Motoko Sasaki
Nozomu Kurose
Masakazu Yamagishi
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2018
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-018-1629-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports

Abstract

Background

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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