Top

Published in:

Open Access 01-12-2017 | Case report

Primary solitary plasmacytoma of the liver – successful treatment with fractionated stereotactic radiotherapy (Cyberknife®): a case report

Authors: Thomas Chalopin, Isabelle Barillot, Jean-Paul Biny, Flavie Arbion, Marie Besson, Maria Santiago-Ribeiro, Eric Piver, Olivier Herault, Emmanuel Gyan, Lotfi Benboubker

Published in: Journal of Medical Case Reports | Issue 1/2017

Abstract

Background

Solitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia. To the best of our knowledge, very few cases have been reported without systemic disease. We reported a rare case of hepatic solitary plasmacytoma that successfully responded to fractionated stereotactic radiotherapy.

Case presentation

A 64-year-old white French man had monoclonal gammopathy of the immune globulin G lambda type; he developed a cholestasis and cytolysis with the discovery of a subscapular nodule. A biopsy showed plasma cells and, for several reasons, the decision was made to use the fractionated stereotactic radiotherapy strategy. After 20 months, he is asymptomatic and the immune globulin G component has completely disappeared.

Conclusion

We suggest considering Cyberknife® radiosurgery as an option for the treatment of hepatic solitary plasmacytoma.

Dimopoulos MA, Hamilos G. Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol. 2002;3:255–9.CrossRefPubMed

Finsinger P, Grammatico S, Chisini M, Piciocchi A, Foa R, Petrucci MT. Clinical features and prognostic factors in solitary plasmacytoma. Br J Haematol. 2016;172(4):554–60.CrossRefPubMed

Petrucci MT, Tirindelli MC, De Muro M, Levi A, Mandelli F. Extramedullary Liver Plasmacytoma: a rare presentation. Leuk Lymphoma. 2003;44(6):1075–6.CrossRefPubMed

Husaric S, Pasic J, Alic E, Kuljanin M. Solitary extramedullary plasmacytoma of the liver. Acta Med Acad. 2013;42(1):85–6.CrossRefPubMed

Knobel D, Zouhair A, Tsang RW, Poortmans P, Belkacemi Y, Bolla M, Oner FD, Landmann C, Castelain B, Ozsahin M. Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study. BMC Cancer. 2006;6:118.CrossRefPubMedPubMedCentral

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Miguel JFS. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538–48.CrossRefPubMed

Ng P, Slater S, Radvan G, Price A. Hepatic plasmacytomas : Case report and review of imaging features. Australas Radiol. 1999;43(1):98–101.CrossRefPubMed

Soutar R, Lucraft H, Jackson G, Reece A, Bird J, Low E, Samson D. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 2004;124:717–26.CrossRefPubMed

Ozsahin M, Tsang RW, Poortmans P, Belkacemi Y, Bolla M, Dincbas FO, Landmann C, Castelain B, Buijsen J, Curschmann J, Kadish SP, Kowalczyk A, Anacak Y, Hammer J, Nguyen TD, Studer G, Cooper R, Sengoz M, Scandolaro L, Zouhair A. Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J Radiat Oncol Biol Phys. 2006;64:210–7.CrossRefPubMed

10.

Wong ET, Lu XQ, Devulapalli J, Mahadevan A. Cyberknife radiosurgery for basal skull plasmacytoma. J Neuroimaging. 2006;16:361–3.CrossRefPubMed

11.

Theiler G, Schwetz V, Gstettner C, Wowra B, Fürweger C, Steiner J, Schmidt HH. Cyberknife radiosurgery leading to long-lasting complete remission in locally relapsed solitary plasmacytoma of the bone. Ann Hematol. 2015;94:1251–3.CrossRefPubMed

12.

Peker S, Abacioglu U, Bayrakli F, Kilic T, Pamir MN. Gamma knife radiosurgery for cavernous sinus plasmacytoma in a patient with breast cancer history. Surg Neurol. 2005;63:174–6. discussion 176–7.CrossRefPubMed

13.

Alafaci C, Grasso G, Conti A, Caffo M, Salpietro FM, Tomasello F. Cyberknife radiosurgery for cranial plasma cell tumor. Turk Neurosurg. 2014;24:272–5.PubMed

14.

Chang UK, Lee DH, Kim MS. Stereotactic radiosurgery for primary malignant spinal tumors. Neurol Res. 2014;36:597–606.CrossRefPubMed

Title: Primary solitary plasmacytoma of the liver – successful treatment with fractionated stereotactic radiotherapy (Cyberknife®): a case report
Authors: Thomas Chalopin
Isabelle Barillot
Jean-Paul Biny
Flavie Arbion
Marie Besson
Maria Santiago-Ribeiro
Eric Piver
Olivier Herault
Emmanuel Gyan
Lotfi Benboubker
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-017-1358-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Primary solitary plasmacytoma of the liver – successful treatment with fractionated stereotactic radiotherapy (Cyberknife®): a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2017

Chest compression-related fatal internal mammary artery injuries manifesting after venoarterial extracorporeal membrane oxygenation: a case series

Hepato-bronchial fistula secondary to perforated sigmoid diverticulitis: a case report

Fever with lymphadenopathy – Kikuchi Fujimoto disease, a great masquerader: a case report

Serum cytokine profile in pediatric Sweet’s syndrome: a case report

Rivaroxaban as an effective alternative to warfarin in a patient with atrial fibrillation, thrombophilia, and left atrial appendage thrombus: a case report

Orthodontic management by functional activator treatment: a case report