Top

Published in:

Open Access 01-12-2017 | Case report

Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature

Authors: Vito Emanuele Catania, Michele Vecchio, Michele Malaguarnera, Roberto Madeddu, Giulia Malaguarnera, Saverio Latteri

Published in: Journal of Medical Case Reports | Issue 1/2017

Abstract

Background

This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.

Case presentation

A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency. This syndrome occurs usually with a hematological tumor, but in this case our patient had a solid tumor, which was a rare extraskeletal osteosarcoma, localized in her pelvic region. She also had lung metastases and bilateral hydronephrosis.

After spontaneous tumor lysis syndrome, she had acute renal insufficiency, which was treated with hemodialysis and successively with rasburicase, Kayexalate (sodium polystyrene sulfonate), and febuxostat.

Conclusion

Tumor lysis syndrome represents an oncological emergency, which must be suspected and treated as soon as possible.

Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011;364(19):1844–54.CrossRefPubMedPubMedCentral

Pumo V, Sciacca D, Malaguarnera M. Tumor lysis syndrome in elderly. Crit Rev Oncol Hematol. 2007;64(1):31–42.CrossRefPubMed

Burns RA, Topoz I, Reynolds SL. Tumor lysis syndrome: risk factors, diagnosis, and management. Pediatr Emerg Care. 2014;30(8):571–6.CrossRefPubMed

Hande KR, Garrow GC. Acute tumor lysis syndrome in patients with high-grade non-Hodgkin’s lymphoma. Am J Med. 1993;94(2):133–9.CrossRefPubMed

Thampi S, Matthay KK, Boscardin WJ, Goldsby R, DuBois SG. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Sarcoma. 2014;2014:902620.CrossRefPubMedPubMedCentral

Mc Auley G, Jagannathan J, O’Regan K, Krajewski KM, Hornick JL, Butrynski J, Ramaiya N. Extraskeletal osteosarcoma: spectrum of imaging findings. AJR Am J Roentgenol. 2012;198(1):W31–7.CrossRefPubMed

Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int. 2011;31(11):1409–17.CrossRefPubMed

Khan J, Broadbent VA. Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma. Pediatr Hematol Oncol. 1993;10(2):151–5.CrossRefPubMed

Gold JE, Malamud SC, LaRosa F, Osband ME. Adoptive chemoimmunotherapy using ex vivo activated memory T-cells and cyclophosphamide: tumor lysis syndrome of a metastatic soft tissue sarcoma. Am J Hematol. 1993;44(1):42–7.CrossRefPubMed

10.

Qian KQ, Ye H, Xiao YW, Bao YY, Qi CJ. Tumor lysis syndrome associated with chemotherapy in primary retroperitoneal soft tissue sarcoma by ex vivo ATP-based tumor chemo-sensitivity assay (ATP-TCA). Int J Gen Med. 2009;2:1–4.PubMedPubMedCentral

11.

Rampello E, Fricia T, Malaguarnera M. The management of tumor lysis syndrome. Nat Clin Pract Oncol. 2006;3(8):438–47.CrossRefPubMed

12.

Hsu HH, Chan YL, Huang CC. Acute spontaneous tumor lysis presenting with hyperuricemic acute renal failure: clinical features and therapeutic approach. J Nephrol. 2004;17(1):50–6.PubMed

13.

Bien E, Maciejka-Kapuscinska L, Niedzwiecki M, Stefanowicz J, Szolkiewicz A, Krawczyk M, Maldyk J, Izycka-Swieszewska E, Tokarska B, Balcerska A. Childhood rhabdomyosarcoma metastatic to bone marrow presenting with disseminated intravascular coagulation and acute tumour lysis syndrome: review of the literature apropos of two cases. Clin Exp Metastasis. 2010;27(6):399–407.CrossRefPubMedPubMedCentral

14.

El-Husseini A, Sabucedo A, Lamarche J, et al. Acute kidney injury associated with tumor lysis syndrome: a paradigm shift. Am J Emerg Med. 2012;30:390. e393–e396.

15.

Mukherjee E, Mukherji D, Jayawardene SA, et al. Tumor lysis syndrome and acute renal failure—an increasing spectrum of presentations. Clin Nephrol. 2007;68:186–9.CrossRefPubMed

16.

Lobe TE, Karkera MS, Custer MD, et al. Fatal refractory hyperkalemia due to tumor lysis during primary resection for hepatoblastoma. J Pediatr Surg. 1990;25:249–50.CrossRefPubMed

17.

Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127:3–11.CrossRefPubMed

18.

Malaguarnera G, Giordano M, Malaguarnera M. Rasburicase for the treatment of tumor lysis in hematological malignancies. Expert Rev Hematol. 2012;5(1):27–38.CrossRefPubMed

Title: Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature
Authors: Vito Emanuele Catania
Michele Vecchio
Michele Malaguarnera
Roberto Madeddu
Giulia Malaguarnera
Saverio Latteri
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-017-1241-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2017

Ruxolitinib found to cause eyelash growth: a case report

Isolated hepatoblastoma arising from the hepatogastric ligament: a case report

Acute myocardial infarction associated with thrombotic microangiopathy following a hump-nosed viper bite: a case report

Carbon dioxide narcosis due to inappropriate oxygen delivery: a case report

Choreoathetosis – an unusual adverse effect of dihydroartemisinin-piperaquine: a case report

Xanthogranulomatous pyelonephritis presenting as acute pleuritic chest pain: a case report