Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2017

Open Access 01-12-2017 | Case report

Merkel cell carcinoma occurring in a black woman: a case report

Published in: Journal of Medical Case Reports | Issue 1/2017

Login to get access

Abstract

Background

Merkel cell carcinoma is a rare, very aggressive neuroectodermal tumor of the skin. It is typically located on sun-exposed skin and frequently found in white men aged between 70 and 80 years.

Case presentation

We report a case of a 58-year-old black woman diagnosed with Merkel cell carcinoma of the posterior face of the right elbow. She had biopsy excision and was lost to follow-up. Four months later, she presented with recurrent disease on the inferior third of the right arm with three ipsilateral axillary lymph node metastases. Amputation of the right arm and ipsilateral axillary lymph node dissection were performed, followed by adjuvant radiotherapy. Six months later, the patient died as a result of respiratory failure caused by lung metastasis. To the best of our knowledge, no specific studies have been done comparing the course and the characteristics of Merkel cell carcinoma in white and black populations, and no similar case has been reported in the literature.

Conclusions

The Merkel cell carcinoma is very rare in black people. As described elsewhere in the literature, our patient had a poor outcome despite radical management. To date, to the best of our knowledge, there has been no comparison of the prognosis of this tumor in white and black populations.
Literature
1.
go back to reference Prieto I, Pérez de la Fuente T, Medina S, Castelo B, Sobrino B, Fortes JR, et al. Merkel cell carcinoma: an algorithm for multidisciplinary management and decision-making. Crit Rev Oncol Hematol. 2016;98:170–9.CrossRefPubMed Prieto I, Pérez de la Fuente T, Medina S, Castelo B, Sobrino B, Fortes JR, et al. Merkel cell carcinoma: an algorithm for multidisciplinary management and decision-making. Crit Rev Oncol Hematol. 2016;98:170–9.CrossRefPubMed
2.
go back to reference Tothill R, Estall V, Rischin D. Merkel cell carcinoma: emerging biology, current approaches and future directions. Am Soc Clin Oncol Educ Book. 2015:e519–26. Tothill R, Estall V, Rischin D. Merkel cell carcinoma: emerging biology, current approaches and future directions. Am Soc Clin Oncol Educ Book. 2015:e519–26.
4.
go back to reference Ratner D, Nelson BR, Brown MD, Johnson TM. Merkel cell carcinoma. J Am Acad Dermatol. 1993;29:143–56.CrossRefPubMed Ratner D, Nelson BR, Brown MD, Johnson TM. Merkel cell carcinoma. J Am Acad Dermatol. 1993;29:143–56.CrossRefPubMed
5.
go back to reference Prieto I, Pardo J, Olivera J, Medina MS, Jover R, Perez AM. Merkel cell carcinoma from 2008 to 2012: reaching a new level of understanding. Cancer Treat Rev. 2013;39:421–9.CrossRef Prieto I, Pardo J, Olivera J, Medina MS, Jover R, Perez AM. Merkel cell carcinoma from 2008 to 2012: reaching a new level of understanding. Cancer Treat Rev. 2013;39:421–9.CrossRef
6.
go back to reference Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol. 2010;37:20–7.CrossRefPubMed Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol. 2010;37:20–7.CrossRefPubMed
7.
go back to reference Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L. Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival. Br J Dermatol. 2011;165:1051–7.CrossRefPubMed Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L. Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival. Br J Dermatol. 2011;165:1051–7.CrossRefPubMed
8.
go back to reference Prewett SL, Ajithkumar T. Merkel cell carcinoma: current management and controversies. Clin Oncol (R Coll Radiol). 2015;27:436–44.CrossRef Prewett SL, Ajithkumar T. Merkel cell carcinoma: current management and controversies. Clin Oncol (R Coll Radiol). 2015;27:436–44.CrossRef
9.
12.
go back to reference Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol. 2001;8:204–8.CrossRefPubMed Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol. 2001;8:204–8.CrossRefPubMed
13.
go back to reference Bichakjian CK, Lowe L, Lao CD, Sandler HM, Bradford CR, Johnson TM, et al. Merkel cell carcinoma: critical review with guidelines for multidisciplinary management. Cancer. 2007;110:1–12.CrossRefPubMed Bichakjian CK, Lowe L, Lao CD, Sandler HM, Bradford CR, Johnson TM, et al. Merkel cell carcinoma: critical review with guidelines for multidisciplinary management. Cancer. 2007;110:1–12.CrossRefPubMed
14.
go back to reference Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol. 2006;28:99–104.CrossRefPubMed Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol. 2006;28:99–104.CrossRefPubMed
16.
go back to reference Calonje E, Brenn T, Lazar A, McKee PH. Tumors of the surface epithelium. In: McKee’s pathology of the skin: with clinical correlations, vol. 2. 4th ed. Philadelphia: Saunders Elsevier; 2012. p. 1076–149.CrossRef Calonje E, Brenn T, Lazar A, McKee PH. Tumors of the surface epithelium. In: McKee’s pathology of the skin: with clinical correlations, vol. 2. 4th ed. Philadelphia: Saunders Elsevier; 2012. p. 1076–149.CrossRef
17.
go back to reference Gonzalez RJ, Padhya TA, Cherpelis BS, Prince MD, Aya-Ay ML, Sondak VK, et al. The surgical management of primary and metastatic Merkel cell carcinoma. Curr Probl Cancer. 2010;34:77–96.CrossRefPubMed Gonzalez RJ, Padhya TA, Cherpelis BS, Prince MD, Aya-Ay ML, Sondak VK, et al. The surgical management of primary and metastatic Merkel cell carcinoma. Curr Probl Cancer. 2010;34:77–96.CrossRefPubMed
18.
go back to reference Guihard S, Noël G. Merkel cell carcinoma, role of radiotherapy and literature review [in French]. Cancer Radiother. 2009;13:47–54.CrossRefPubMed Guihard S, Noël G. Merkel cell carcinoma, role of radiotherapy and literature review [in French]. Cancer Radiother. 2009;13:47–54.CrossRefPubMed
19.
go back to reference Lemos BD, Storer BE, Iyer JG, Phillips JL, Bichakjian CK, Fang LC, et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010;63:751–61.CrossRefPubMedPubMedCentral Lemos BD, Storer BE, Iyer JG, Phillips JL, Bichakjian CK, Fang LC, et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010;63:751–61.CrossRefPubMedPubMedCentral
20.
go back to reference Tai PT, Yu E, Tonita J, Gilchrist J. Merkel cell carcinoma of the skin. J Cutan Med Surg. 2000;4:186–95.PubMed Tai PT, Yu E, Tonita J, Gilchrist J. Merkel cell carcinoma of the skin. J Cutan Med Surg. 2000;4:186–95.PubMed
21.
go back to reference Howle JR, Hughes TM, Gebski V, Veness MJ. Merkel cell carcinoma: an Australian perspective and the importance of addressing the regional lymph nodes in clinically node negative patients. J Am Acad Dermatol. 2012;67:33–40.CrossRefPubMed Howle JR, Hughes TM, Gebski V, Veness MJ. Merkel cell carcinoma: an Australian perspective and the importance of addressing the regional lymph nodes in clinically node negative patients. J Am Acad Dermatol. 2012;67:33–40.CrossRefPubMed
22.
go back to reference Sarnaik AA, Lien MH, Nghiem P, Bichakjian CK. Clinical recognition, diagnosis, and staging of Merkel cell carcinoma, and the role of the multidisciplinary management team. Curr Probl Cancer. 2010;34:38–46.CrossRefPubMed Sarnaik AA, Lien MH, Nghiem P, Bichakjian CK. Clinical recognition, diagnosis, and staging of Merkel cell carcinoma, and the role of the multidisciplinary management team. Curr Probl Cancer. 2010;34:38–46.CrossRefPubMed
23.
go back to reference Fields RC, Busam KJ, Chou JF, Panageas KS, Pulitzer MP, Allen PJ, et al. Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma. Cancer. 2012;118:3311–20.CrossRefPubMed Fields RC, Busam KJ, Chou JF, Panageas KS, Pulitzer MP, Allen PJ, et al. Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma. Cancer. 2012;118:3311–20.CrossRefPubMed
24.
go back to reference Salvador Alonso R, Lahbabi I, Ben Hassel M, Boisselier P, Chaari N, Lesimple T, et al. Merkel cell carcinoma: outcome and role of radiotherapy [in French]. Cancer Radiother. 2008;12:352–9.CrossRefPubMed Salvador Alonso R, Lahbabi I, Ben Hassel M, Boisselier P, Chaari N, Lesimple T, et al. Merkel cell carcinoma: outcome and role of radiotherapy [in French]. Cancer Radiother. 2008;12:352–9.CrossRefPubMed
Metadata
Title
Merkel cell carcinoma occurring in a black woman: a case report
Publication date
01-12-2017
Published in
Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-016-1189-8

Other articles of this Issue 1/2017

Journal of Medical Case Reports 1/2017 Go to the issue