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Published in: Journal of Medical Case Reports 1/2016

Open Access 01-12-2016 | Case report

Concurrent colonic mucosa-associated lymphoid tissue lymphoma and adenoma diagnosed after a positive fecal occult blood test: a case report

Authors: Pei-Chiang Lin, Jinn-Shiun Chen, Po Deng, Chih-Wei Wang, Chiung-Huei Huang, Reiping Tang, Jy-Ming Chiang, Chien-Yuh Yeh, Pao-Shiu Hsieh, Wen-Sy Tsai, Sum-Fu Chiang

Published in: Journal of Medical Case Reports | Issue 1/2016

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Abstract

Background

Colonic lymphoma is an uncommon presentation of extranodal lymphoma. Colonic mucosa-associated lymphoid tissue lymphoma is a different entity from gastric mucosa-associated lymphoid tissue lymphoma, and very rare. The presentation and management of colonic mucosa-associated lymphoid tissue are highly variable in the literature.

Case presentation

We report the case of a 59-year-old Taiwanese man who underwent a colonoscopy after a positive test for fecal occult blood. His past history included hypertension and hyperthyroidism. The colonoscopy revealed an adenomatous polyp and mucosa-associated lymphoid tissue lymphoma. We successfully performed a polypectomy and endoscopic mucosal resection. The lymphoma was staged according to the Ann Arbor system modified by Musshoff as E-I. Our patient showed no lymphoma recurrence over a 3-year follow-up.

Conclusions

Endoscopic mucosal resection for colonic mucosa-associated lymphoid tissue lymphoma without disseminated disease may be feasible. We successfully used colonoscopic treatment without adjuvant therapy to treat early-stage pathogen-free colonic mucosa-associated lymphoid tissue lymphoma.
Literature
1.
go back to reference Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001;19(18):3861–73.CrossRefPubMed Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001;19(18):3861–73.CrossRefPubMed
2.
go back to reference Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol. 2008;19(12):1992–9.CrossRefPubMedPubMedCentral Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol. 2008;19(12):1992–9.CrossRefPubMedPubMedCentral
3.
go back to reference Doolabh N, Anthony T, Simmang C, Bieligk S, Lee E, Huber P, et al. Primary colonic lymphoma. J Surg Oncol. 2000;74(4):257–62.CrossRefPubMed Doolabh N, Anthony T, Simmang C, Bieligk S, Lee E, Huber P, et al. Primary colonic lymphoma. J Surg Oncol. 2000;74(4):257–62.CrossRefPubMed
4.
go back to reference Fan CW, Changchien CR, Wang JY, Chen JS, Hsu KC, Tang R, et al. Primary colorectal lymphoma. Dis Colon Rectum. 2000;43(9):1277–82.CrossRefPubMed Fan CW, Changchien CR, Wang JY, Chen JS, Hsu KC, Tang R, et al. Primary colorectal lymphoma. Dis Colon Rectum. 2000;43(9):1277–82.CrossRefPubMed
5.
go back to reference Pileri SA, Milani M, Fraternali-Orcioni G, Sabattini E. From the REAL-classification to the upcoming WHO-scheme: a step towards universal categorization of lymphoma’s entities? Ann Oncol. 1998;9(6):607–12.CrossRefPubMed Pileri SA, Milani M, Fraternali-Orcioni G, Sabattini E. From the REAL-classification to the upcoming WHO-scheme: a step towards universal categorization of lymphoma’s entities? Ann Oncol. 1998;9(6):607–12.CrossRefPubMed
6.
go back to reference Schmid C, Vazquez JJ, Diss TC, Isaacson PG. Primary B-cell mucosa-associated lymphoid tissue lymphoma presenting as a solitary colorectal polyp. Histopathology. 1994;24:357–62.CrossRefPubMed Schmid C, Vazquez JJ, Diss TC, Isaacson PG. Primary B-cell mucosa-associated lymphoid tissue lymphoma presenting as a solitary colorectal polyp. Histopathology. 1994;24:357–62.CrossRefPubMed
7.
go back to reference Raderer M, Pfeffel F, Pohl G, Mannhalter C, Valencak J, Chott A. Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. Gut. 2000;46:133–5.CrossRefPubMedPubMedCentral Raderer M, Pfeffel F, Pohl G, Mannhalter C, Valencak J, Chott A. Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. Gut. 2000;46:133–5.CrossRefPubMedPubMedCentral
8.
go back to reference Lee YG, Lee S, Han SW, Lee JS. A case of multiple mucosa-associated lymphoid tissue (MALT) lymphoma of the colon identified as simple mucosal discoloration. J Korean Med Sci. 2005;20(2):325–8.CrossRefPubMedPubMedCentral Lee YG, Lee S, Han SW, Lee JS. A case of multiple mucosa-associated lymphoid tissue (MALT) lymphoma of the colon identified as simple mucosal discoloration. J Korean Med Sci. 2005;20(2):325–8.CrossRefPubMedPubMedCentral
9.
go back to reference Kanneganti K, Bhavna B. Mucosa-associated lymphoid tissue lymphoma presenting as massive gastrointestinal bleeding: a case report. Case Rep Gastroentrol. 2008;2:296–300.CrossRef Kanneganti K, Bhavna B. Mucosa-associated lymphoid tissue lymphoma presenting as massive gastrointestinal bleeding: a case report. Case Rep Gastroentrol. 2008;2:296–300.CrossRef
10.
go back to reference Ferreira R, Torres J, Raposo J, Duarte MB, Pereira MJ, Carvalheiro J, et al. Multifocal colonic mucosa-associated lymphoid tissue lymphoma with synchronous tubular adenoma: a coincidental association? Int J Colorectal Dis. 2011;26(9):1221–2.CrossRefPubMed Ferreira R, Torres J, Raposo J, Duarte MB, Pereira MJ, Carvalheiro J, et al. Multifocal colonic mucosa-associated lymphoid tissue lymphoma with synchronous tubular adenoma: a coincidental association? Int J Colorectal Dis. 2011;26(9):1221–2.CrossRefPubMed
11.
go back to reference Akasaka R, Chiba T, Dutta AK, Toya Y, Mizutani T, Shozushima T, et al. Colonic mucosa-associated lymphoid tissue lymphoma. Case Rep Gastroenterol. 2012;6(2):569–75.CrossRefPubMedPubMedCentral Akasaka R, Chiba T, Dutta AK, Toya Y, Mizutani T, Shozushima T, et al. Colonic mucosa-associated lymphoid tissue lymphoma. Case Rep Gastroenterol. 2012;6(2):569–75.CrossRefPubMedPubMedCentral
12.
go back to reference Musshoff K. Clinical staging classification of non-Hodgkin’s lymphomas (author’s transl). Strahlentherapie. 1977;153(5):218–21.PubMed Musshoff K. Clinical staging classification of non-Hodgkin’s lymphomas (author’s transl). Strahlentherapie. 1977;153(5):218–21.PubMed
13.
go back to reference Isaacson PG, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983;52:1410–6.CrossRefPubMed Isaacson PG, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983;52:1410–6.CrossRefPubMed
15.
go back to reference Asenjo LM, Gisbert JP. Prevalence of Helicobacter pylori infection in gastric MALT lymphoma: a systematic review. Rev Esp Enferm Dig. 2007;99:398–404.CrossRefPubMed Asenjo LM, Gisbert JP. Prevalence of Helicobacter pylori infection in gastric MALT lymphoma: a systematic review. Rev Esp Enferm Dig. 2007;99:398–404.CrossRefPubMed
16.
go back to reference Nakamura S, Yao T, Aoyagi K, Iida M, Fujishima M, Tsuneyoshi M. Helicobacter pylori and primary gastric lymphoma. A histopathologic and immunohistochemical analysis of 237 patients. Cancer. 1997;79:3–11.CrossRefPubMed Nakamura S, Yao T, Aoyagi K, Iida M, Fujishima M, Tsuneyoshi M. Helicobacter pylori and primary gastric lymphoma. A histopathologic and immunohistochemical analysis of 237 patients. Cancer. 1997;79:3–11.CrossRefPubMed
17.
go back to reference Gisbert JP, Calvet X. Review article: common misconceptions in the management of Helicobacter pylori-associated gastric MALT-lymphoma. Aliment Pharmacol Ther. 2011;34(9):1047–62.CrossRefPubMed Gisbert JP, Calvet X. Review article: common misconceptions in the management of Helicobacter pylori-associated gastric MALT-lymphoma. Aliment Pharmacol Ther. 2011;34(9):1047–62.CrossRefPubMed
18.
go back to reference Chen LT, Lin JT, Tai JJ, Chen GH, Yeh HZ, Yang SS, et al. Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma. J Natl Cancer Inst. 2005;97:1345–53.CrossRefPubMed Chen LT, Lin JT, Tai JJ, Chen GH, Yeh HZ, Yang SS, et al. Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma. J Natl Cancer Inst. 2005;97:1345–53.CrossRefPubMed
19.
go back to reference Hong SS, Jung HY, Choi KD, Song HJ, Lee GH, Oh TH, et al. A prospective analysis of low-grade gastric malt lymphoma after Helicobacter pylori eradication. Helicobacter. 2006;11(6):569–73.CrossRefPubMed Hong SS, Jung HY, Choi KD, Song HJ, Lee GH, Oh TH, et al. A prospective analysis of low-grade gastric malt lymphoma after Helicobacter pylori eradication. Helicobacter. 2006;11(6):569–73.CrossRefPubMed
20.
go back to reference Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T. Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: a review. World J Gastroenterol. 2015;21(26):8014–20.CrossRefPubMedPubMedCentral Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T. Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: a review. World J Gastroenterol. 2015;21(26):8014–20.CrossRefPubMedPubMedCentral
21.
go back to reference Kaneko Y, Kojima M, Suzuki S, Takada A, Yamagishi H, Nakazato Y, et al. Atypical interfollicular hyperplasia of tonsils resembling mucosa-associated lymphoid tissue lymphoma: a clinicopathological, immunohistochemical study and Epstein-Barr virus findings in 12 cases. J Clin Exp Hematop. 2014;54(2):111–6.CrossRefPubMed Kaneko Y, Kojima M, Suzuki S, Takada A, Yamagishi H, Nakazato Y, et al. Atypical interfollicular hyperplasia of tonsils resembling mucosa-associated lymphoid tissue lymphoma: a clinicopathological, immunohistochemical study and Epstein-Barr virus findings in 12 cases. J Clin Exp Hematop. 2014;54(2):111–6.CrossRefPubMed
22.
go back to reference Rubenstein JN, Beatty C, Kinkade Z, Bryan C, Hogg JP, Gibson LF et al. Extranodal marginal zone lymphoma of the lung: evolution from an underlying reactive lymphoproliferative disorder. J Clin Exp Pathol. 2015;5(1) Rubenstein JN, Beatty C, Kinkade Z, Bryan C, Hogg JP, Gibson LF et al. Extranodal marginal zone lymphoma of the lung: evolution from an underlying reactive lymphoproliferative disorder. J Clin Exp Pathol. 2015;5(1)
23.
go back to reference Kiesewetter B, Lukas J, Kuchar A, Mayerhoefer ME, Streubel B, Lagler H, et al. Clinical features, treatment and outcome of mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa: single center experience of 60 patients. PLoS One. 2014;9(7):e104004.CrossRefPubMedPubMedCentral Kiesewetter B, Lukas J, Kuchar A, Mayerhoefer ME, Streubel B, Lagler H, et al. Clinical features, treatment and outcome of mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa: single center experience of 60 patients. PLoS One. 2014;9(7):e104004.CrossRefPubMedPubMedCentral
24.
go back to reference Jain V, Misra S, Ahmad F, Rahul K, Singh A. MALT lymphoma of caecum presenting as acute intestinal obstruction: a case report. Indian J Surg. 2013;75 Suppl 1:286–9.CrossRefPubMed Jain V, Misra S, Ahmad F, Rahul K, Singh A. MALT lymphoma of caecum presenting as acute intestinal obstruction: a case report. Indian J Surg. 2013;75 Suppl 1:286–9.CrossRefPubMed
25.
go back to reference Terada T. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in ulcerative colitis. Saudi J Gastroenterol. 2014;20(5):319–22.CrossRefPubMedPubMedCentral Terada T. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in ulcerative colitis. Saudi J Gastroenterol. 2014;20(5):319–22.CrossRefPubMedPubMedCentral
Metadata
Title
Concurrent colonic mucosa-associated lymphoid tissue lymphoma and adenoma diagnosed after a positive fecal occult blood test: a case report
Authors
Pei-Chiang Lin
Jinn-Shiun Chen
Po Deng
Chih-Wei Wang
Chiung-Huei Huang
Reiping Tang
Jy-Ming Chiang
Chien-Yuh Yeh
Pao-Shiu Hsieh
Wen-Sy Tsai
Sum-Fu Chiang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2016
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-016-0810-1

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