Top

Journal of Medical Case Reports

Published in:

Open Access 01-12-2015 | Case report

Metastasized pancreatic neuroendocrine tumor in a teenage girl: a case report

Authors: Tina Tremmel, Stefan Holland-Cunz, Patrick Günther

Published in: Journal of Medical Case Reports | Issue 1/2015

Abstract

Introduction

Metastasized pancreatic neuroendocrine tumors are extremely rare malignancies, especially in children. Therefore, therapeutic options are limited, and few standardized therapy regimens exist.

Case presentation

We report a case of a 14-year-old white girl. In 2011 she was diagnosed with a metastasized, well-differentiated pancreatic neuroendocrine tumor with expression of synaptophysin and chromogranin A. We describe her clinical course with special attention to her individual therapeutic regimens while bringing together several disciplines of medicine.

Conclusions

In patients such as ours, surgical intervention may be the only therapy that will lead to long-term survival.

Delaunoit T, Neczyporenko F, Rubin J, Erlichman C, Hobday TJ. Medical management of pancreatic neuroendocrine tumors. Am J Gastroenterol. 2008;103:475–83.CrossRefPubMed

Ehehalt F, Saeger HD, Schmidt CM, Grützmann R. Neuroendocrine tumors of the pancreas. Oncologist. 2009;14:456–67.CrossRefPubMed

Falconi M, Bartsch DK, Eriksson B, Klöppel G, Lopes JM, O’Connor JM, et al. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non-functioning tumors. Neuroendocrinology. 2012;95:120–34.CrossRefPubMed

Gläsker S, Neumann HPH, Koch CA, Vortmeyer AO. Von Hippel-Lindau Syndrome. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext. South Dartmouth: MDText.com; 2012.

Howell DL, O’Dorisio MS. Management of neuroendocrine tumors in children, adolescents, and young adults. J Pediatr Hematol Oncol. 2012;34 Suppl 2:S64–68.CrossRefPubMed

Lachter J, Arkovitz MS, Postovski S, Waldner JM, Shaoul R, Ishay OB, et al. EUS-FNA for a pancreatic neuroendocrine tumor in a four-year-old daughter of a woman exposed to radiation at Chernobyl. Case Rep Gastrointest Med. 2012;2012:462139.PubMedPubMedCentral

Marchegiani G, Crippa S, Malleo G, Partelli S, Capelli P, Pederzoli P, et al. Surgical treatment of pancreatic tumors in childhood and adolescence: uncommon neoplasms with favorable outcome. Pancreatology. 2011;11:383–9.CrossRefPubMed

Grozinsky-Glasberg S, Gross DJ. New drugs in the therapy of neuroendocrine tumors. J Endocrinol Invest. 2012;35:930–6.PubMed

Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol. 2006;24:401–6.CrossRefPubMed

10.

Rojas Y, Warneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, et al. Primary malignant pancreatic neoplasms in children and adolescents: a 20 year experience. J Pediatr Surg. 2012;47:2199–204.CrossRefPubMed

11.

Perez EA, Gutierrez JC, Koniaris LG, Neville HL, Thompson WR, Sola JE. Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients. J Pediatr Surg. 2009;44:197–203.CrossRefPubMed

12.

National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) program. http://seer.cancer.gov/

Title: Metastasized pancreatic neuroendocrine tumor in a teenage girl: a case report
Authors: Tina Tremmel
Stefan Holland-Cunz
Patrick Günther
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-015-0708-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Metastasized pancreatic neuroendocrine tumor in a teenage girl: a case report

Abstract

Introduction

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2015

A 42-year-old patient presenting with femoral head migration after hemiarthroplasty performed 22 years earlier: a case report

Set screw fracture with cage dislocation after two-level transforaminal lumbar interbody fusion (TLIF): a case report

Simultaneous occurrence of a severe Morel-Lavallée lesion and gluteal muscle necrosis as a sequela of transcatheter angiographic embolization following pelvic fracture: a case report

Remote cerebellar hemorrhage following thoracic spinal surgery of an intradural extramedullary tumor: a case report

Coronary artery bypass grafting in Takayasu’s disease – importance of the proximal anastomosis: a case report

Leptospirosis infection in a homeless patient in December in Tokyo: a case report