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Open Access 01-12-2015 | Case report

Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report

Authors: Rajitha Asanga Abeysekera, Abdul Wahid Mohomad Wazil, Nishantha Nanayakkara, Neelakanthi Ratnatunga, Kaushal Maithree Fernando, Jalitha Thinnarachchi

Published in: Journal of Medical Case Reports | Issue 1/2015

Abstract

Introduction

Kidney involvement in non-Hodgkin lymphoma is recognized but mostly diagnosed following a diagnosis of lymphoma. We describe a rare case of mantle cell lymphoma, a B-cell-type non-Hodgkin lymphoma, first presenting with immune complex glomerulonephritis.

Case presentation

We report the case of a 58-year-old Sri Lankan man who presented with gross hematuria. Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine. He had a renal biopsy, which revealed acute immune complex glomerulonephritis with interstitial inflammation. Results from an initial bone marrow biopsy and blood imaging were inconclusive. Three months later his renal function had deteriorated and a lymph node biopsy revealed mantle cell lymphoma. Within three months of initiating chemotherapy, his renal function returned to normal levels and remained normal at one year of follow-up.

Conclusions

It is important to have a high degree of suspicion when patients present with acute immune complex glomerulonephritis with no other identifiable cause, because it could be the first presentation of a non-Hodgkin lymphoma such as mantle cell lymphoma.

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Title: Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report
Authors: Rajitha Asanga Abeysekera
Abdul Wahid Mohomad Wazil
Nishantha Nanayakkara
Neelakanthi Ratnatunga
Kaushal Maithree Fernando
Jalitha Thinnarachchi
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-015-0583-y

At a glance: The STEP trials

Springer Medicine

Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report

Abstract

Introduction

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

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