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Insights into Imaging
Published in: Insights into Imaging 1/2019

Open Access 01-12-2019 | Lymphoma | Pictorial Review

Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know

Authors: Francesco Alessandrino, Pamela J. DiPiro, Jyothi P. Jagannathan, Gosangi Babina, Katherine M. Krajewski, Nikhil H. Ramaiya, Angela A. Giardino

Published in: Insights into Imaging | Issue 1/2019

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Abstract

Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation.
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Metadata
Title
Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
Authors
Francesco Alessandrino
Pamela J. DiPiro
Jyothi P. Jagannathan
Gosangi Babina
Katherine M. Krajewski
Nikhil H. Ramaiya
Angela A. Giardino
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 1/2019
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1186/s13244-019-0705-y

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