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Molecular Autism
Published in: Molecular Autism 1/2016

Open Access 01-12-2016 | Review

From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition

Authors: Adam M. H. Young, Bhismadev Chakrabarti, David Roberts, Meng-Chuan Lai, John Suckling, Simon Baron-Cohen

Published in: Molecular Autism | Issue 1/2016

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Abstract

Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed.
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Metadata
Title
From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
Authors
Adam M. H. Young
Bhismadev Chakrabarti
David Roberts
Meng-Chuan Lai
John Suckling
Simon Baron-Cohen
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Molecular Autism / Issue 1/2016
Electronic ISSN: 2040-2392
DOI
https://doi.org/10.1186/s13229-016-0068-x

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