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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2017

Open Access 01-12-2017 | Research

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

Authors: Ping Li, Zhongjuan Liu, Ziyan Wu, Xiaoting Wen, Liubing Li, Shulan Zhang, Yingchun Xu, Yongzhe Li

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2017

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Abstract

Objective

To determine the adult reference intervals for the Siemens IgG subclass reagents.

Methods

636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits.

Results

IgGSc reference intervals were as follows: IgG1 4.45–9.76 g/L, IgG2 2.07–8.57 g/L, IgG3 0.08–0.80 g/L and IgG4 0.05–1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed.

Conclusions

Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.
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Metadata
Title
Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
Authors
Ping Li
Zhongjuan Liu
Ziyan Wu
Xiaoting Wen
Liubing Li
Shulan Zhang
Yingchun Xu
Yongzhe Li
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2017
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-017-0216-7

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