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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2017

Open Access 01-12-2017 | Research

Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma

Authors: L. Montrose, T. J. Ward, E. O. Semmens, Y. H. Cho, B. Brown, C. W. Noonan

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2017

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Abstract

Background

Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or hyper-methylation have been shown to occur in response to environmental exposures including dietary nutrients.

Methods

Within the context of the asthma randomized trial of indoor wood smoke (ARTIS) study, we investigated relationships between diet, asthma health measures, and DNA methylation. Asthma health measures included a quality of life instrument, diurnal peak flow variability (dPFV) and forced expiratory volume in the first second (FEV1). Dietary intake was assessed with a food frequency questionnaire. Methylation levels of LINE-1 repetitive element and two promoter CpG sites for interferon gamma (IFNγ, -186 and -54) from buccal cell DNA were measured using pyrosequencing assays.

Results

Data were collected on 32 children with asthma living in western Montana who were recruited to the ARTIS study. Selenium and several methyl donor dietary nutrients were positively associated with the asthma quality of life measure. Intake of methyl donating nutrients including folate was positively associated LINE-1 methylation and negatively associated with IFNγ CpG-186. Higher levels of LINE-1 methylation were associated with greater dPFV.

Conclusion

We identified several nutrients that were associated with improved quality of life measures among children with asthma. The IFNγ promoter CpG site -186 but not -54 was associated with the intake of selected dietary nutrients. However, in this small population of children with asthma, the IFNγ promoter CpG sites were not associated with respiratory health measures so it remains unclear through which epigenetic mechanism these nutrients are impacting the quality of life measure. These findings add to the evidence that dietary nutrients, particularly foods containing methyl donors, may be important for epigenetic regulation as it pertains to the control of asthma.
Trial registration ClincialTrials.gov NCT00807183. Registered 10 December 2008
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Literature
1.
Akinbami LJ, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief. 2012;94:1–8.
2.
3.
Thuesen BH, et al. Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults. Allergy. 2010;65(11):1446–54.CrossRefPubMed
4.
Mehta AK, et al. Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma. Immunobiology. 2010;215(7):527–34.CrossRefPubMed
5.
Barros R, et al. Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control. Allergy. 2008;63(7):917–23.CrossRefPubMed
6.
Barros R, et al. Dietary intake of alpha-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. Br J Nutr. 2011;106(3):441–50.CrossRefPubMed
7.
Castro-Rodriguez JA, et al. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr. 2008;152(6):823–8.CrossRefPubMed
8.
Chatzi L, et al. Diet, wheeze, and atopy in school children in Menorca, Spain. Pediatr Allergy Immunol. 2007;18(6):480–5.CrossRefPubMed
9.
Chatzi L, et al. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax. 2008;63(6):507–13.CrossRefPubMed
10.
de Batlle J, et al. Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy. 2008;63(10):1310–6.CrossRefPubMed
11.
Garcia-Marcos L, et al. Relationship of asthma and rhinoconjunctivitis with obesity, exercise and Mediterranean diet in Spanish schoolchildren. Thorax. 2007;62(6):503–8.CrossRefPubMedPubMedCentral
12.
Romieu I, et al. Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants. Respir Res. 2009;10:122.CrossRefPubMedPubMedCentral
13.
14.
Berthon BS, et al. Investigation of the association between dietary intake, disease severity and airway inflammation in asthma. Respirology. 2013;18(3):447–54.CrossRefPubMed
15.
Cortessis VK, et al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships. Hum Genet. 2012;131(10):1565–89.CrossRefPubMedPubMedCentral
16.
Lovinsky-Desir S, Miller RL. Epigenetics, asthma, and allergic diseases: a review of the latest advancements. Curr Allergy Asthma Rep. 2012;12(3):211–20.CrossRefPubMedPubMedCentral
17.
18.
Bansal P, et al. Intranasal administration of a combination of choline chloride, vitamin C, and selenium attenuates the allergic effect in a mouse model of airway disease. Free Radic Biol Med. 2014;73:358–65.CrossRefPubMed
19.
North ML, Ellis AK. The role of epigenetics in the developmental origins of allergic disease. Ann Allergy Asthma Immunol. 2011;106(5):355–61.CrossRefPubMed
20.
Dolinoy DC. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev. 2008;66(Suppl 1):S7–11.CrossRefPubMedPubMedCentral
21.
Hollingsworth JW, et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest. 2008;118(10):3462–9.PubMedPubMedCentral
22.
23.
Nadeau K, et al. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol. 2010;126(4):845–52.CrossRefPubMed
24.
Friso S, et al. One-carbon metabolism and epigenetics. Mol Aspects Med. 2016.
25.
Calderon C, et al. T-cell cytokine profiles are altered in childhood asthma exacerbation. Respirology. 2009;14(2):264–9.CrossRefPubMed
26.
Crinnion WJ. Do environmental toxicants contribute to allergy and asthma? Altern Med Rev. 2012;17(1):6–18.PubMed
27.
Smart JM, et al. Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses. J Allergy Clin Immunol. 2002;110(3):450–6.CrossRefPubMed
28.
Meng H, et al. In vitro production of IL-6 and IFN-gamma is influenced by dietary variables and predicts upper respiratory tract infection incidence and severity respectively in young adults. Front Immunol. 2015;6:94.CrossRefPubMedPubMedCentral
29.
Mohammadi-Shahrokhi V, et al. Immunomodulatory effects of adjuvants CPG, MPLA, and BCG on the Derp2-induced acute asthma at early life in an animal model of BALB/c Mice. Inflammation. 2016.
30.
Santeliz JV, et al. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol. 2002;109(3):455–62.CrossRefPubMed
31.
32.
Ward TJ, et al. Efficacy of interventions targeting household air pollution from residential wood stoves. J Expo Sci Environ Epidemiol. 2017;27(1):64–71.CrossRefPubMed
33.
34.
35.
Block G, et al. Revision of dietary analysis software for the health habits and history questionnaire. Am J Epidemiol. 1994;139(12):1190–6.CrossRefPubMed
36.
Block G, DiSogra C. WIC dietary assessment validation study. Final report. Alexandria: US Department of Agriculture, Food and Nutrition Service; 1995.
37.
Block G, et al. Comparison of two dietary questionnaires validated against multiple dietary records collected during a 1-year period. J Am Diet Assoc. 1992;92:686–93.PubMed
38.
Block G, et al. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990;43(12):1327–35.CrossRefPubMed
39.
Juniper EF, et al. Measuring quality of life in children with asthma. Qual Life Res. 1996;5(1):35–46.CrossRefPubMed
40.
Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J R Stat Soc Series B-Methodol. 1995;57(1):289–300.
41.
Lung National Heart, Institute Blood. Expert panel report 3: guidelines for the diagnosis and management of asthma. Bethesda: National Heart Lung, and Blood Institute; 2007.
42.
Sharma S, Litonjua A. Asthma, allergy, and responses to methyl donor supplements and nutrients. J Allergy Clin Immunol. 2014;133(5):1246–54.CrossRefPubMed
43.
44.
Crider KS, et al. Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(5):1272–81.CrossRefPubMed
45.
Lin JH, et al. Relationships between folate and inflammatory features of asthma. J Allergy Clin Immunol. 2013;131(3):918–20.CrossRefPubMed
46.
47.
Farres MN, et al. Study of folate status among Egyptian asthmatics. Intern Med. 2011;50(3):205–11.CrossRefPubMed
48.
Blatter J, et al. Folate deficiency, atopy, and severe asthma exacerbations in Puerto Rican children. Ann Am Thorac Soc. 2016;13(2):223–30.PubMedPubMedCentral
49.
Fabian E, et al. Nutritional supplements and plasma antioxidants in childhood asthma. Wien Klin Wochenschr. 2013;125(11–12):309–15.CrossRefPubMed
50.
Rosenlund H, et al. Antioxidant intake and allergic disease in children. Clin Exp Allergy. 2012;42(10):1491–500.CrossRefPubMed
51.
52.
Pollock AH, et al. Prolonged Intake of dietary lipids alters membrane structure and T cell responses in LDLr−/− Mice. J Immunol. 2016;196(10):3993–4002.CrossRefPubMed
53.
54.
de Pablo MA, Puertollano MA, Alvarez de Cienfuegos G. Biological and clinical significance of lipids as modulators of immune system functions. Clin Diagn Lab Immunol. 2002;9(5):945–50.PubMed
55.
56.
57.
58.
Liu J, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci. 2008;102(1):76–81.CrossRefPubMed
59.
Brand S, et al. DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma. J Allergy Clin Immunol. 2012;29(6):1602–10.CrossRef
60.
61.
Kohli A, et al. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children. Clin Epigenetics. 2012;4(1):17.CrossRefPubMedPubMedCentral
62.
White GP, et al. CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics. Pediatr Allergy Immunol. 2006;17(8):557–64.CrossRefPubMed
63.
64.
Lovinsky-Desir S, et al. DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics. Clin Epigenetics. 2014;6(1):9.CrossRefPubMedPubMedCentral
65.
66.
Huang SL, Pan WH. Dietary fats and asthma in teenagers: analyses of the first Nutrition and Health Survey in Taiwan (NAHSIT). Clin Exp Allergy. 2001;31(12):1875–80.CrossRefPubMed
67.
Heinrich J, et al. Allergic sensitization and diet: ecological analysis in selected European cities. Eur Respir J. 2001;17(3):395–402.CrossRefPubMed
Metadata
Title
Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma
Authors
L. Montrose
T. J. Ward
E. O. Semmens
Y. H. Cho
B. Brown
C. W. Noonan
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2017
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-017-0187-8

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