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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2016

Open Access 01-12-2016 | Research

Persistence of respiratory and inflammatory responses after dermal sensitization to persulfate salts in a mouse model of non-atopic asthma

Authors: M. J. Cruz, M. Olle-Monge, J. A. Vanoirbeek, A. Assialioui, S. Gomez-Olles, X. Muñoz

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2016

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Abstract

Background

Exposure to ammonium persulfate (AP) has been reported to be the main cause of occupational asthma in hairdressers. The aim of this study is to assess how long the asthmatic response to AP can be induced after dermal sensitization in a mouse model.

Methods

BALB/c mice received dermal applications of AP or dimethylsulfoxide (DMSO) (control) on days 1 and 8. They then received a single nasal instillation (challenge) of AP or saline on days 15, 22, 29, 36, 45, 60 and 90. Respiratory responsiveness to methacholine was measured 24 h after the challenge using a non-specific methacholine provocation test. Pulmonary inflammation was analysed in bronchoalveolar lavage (BAL), and total serum immunoglobulin (Ig) E, IgG1 and IgG2a were measured in serum samples. Histological analysis of lung slides was performed.

Results

Mice dermally sensitized and intranasally challenged with AP showed respiratory responsiveness to methacholine as long as 45 days after initial sensitization, as well as increased percentage of neutrophils in BAL compared with the control group. At day 60, dermally sensitized mice still presented bronchial hyperresponsiveness, while the percentage of neutrophils returned to baseline levels similar to those of controls. Total serum IgE increased significantly on day 22 after dermal sensitization. Total serum IgG1 and IgG2a increased from 45 days after dermal sensitization and remained high at 90 days.

Conclusions

Both respiratory responsiveness to methacholine and airway inflammation responses decrease with increasing time between sensitization and challenge. Respiratory responsiveness to methacholine tends to persist longer than inflammation.
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Metadata
Title
Persistence of respiratory and inflammatory responses after dermal sensitization to persulfate salts in a mouse model of non-atopic asthma
Authors
M. J. Cruz
M. Olle-Monge
J. A. Vanoirbeek
A. Assialioui
S. Gomez-Olles
X. Muñoz
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2016
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-016-0131-3

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