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Published in: Trials 1/2019

Open Access 01-12-2019 | Abdominal Surgery | Study protocol

Do antibacterial skin sutures reduce surgical site infections after elective open abdominal surgery? - Study protocol of a prospective, randomized controlled single center trial

Authors: Daniel Matz, Saskia Teuteberg, Andrea Wiencierz, Savas Deniz Soysal, Oleg Heizmann

Published in: Trials | Issue 1/2019

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Abstract

Background

Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk of SSI. In line with in-vitro results, we hypothesize that the use of antibacterial skin sutures (triclosan-coated poliglecaprone 25) reduces the rate of SSI after open abdominal surgery.

Methods/design

To prevent SSI, triclosan-coated poliglecaprone 25 sutures will be tested against un-coated suture material for skin closure after elective open abdominal surgery of 364 patients. The study is planned as a single-center, prospective randomized controlled trial. Patients will be followed for 30 days after surgery to detect and document wound complications. The rate of SSI after 30 days will be analyzed in both groups.

Discussion

If we can confirm the proposed hypothesis in our study, this could be a promising and feasible approach to lower SSI after open abdominal surgery. By lowering the rate of SSI this might offer a cost-saving and morbidity-reducing procedure.

Trial registration

German Clinical Trials Register, DRKS00010047. Registered on 05.01.2017.
Appendix
Available only for authorised users
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Metadata
Title
Do antibacterial skin sutures reduce surgical site infections after elective open abdominal surgery? - Study protocol of a prospective, randomized controlled single center trial
Authors
Daniel Matz
Saskia Teuteberg
Andrea Wiencierz
Savas Deniz Soysal
Oleg Heizmann
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Trials / Issue 1/2019
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-019-3492-3

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