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Trials
Published in: Trials 1/2018

Open Access 01-12-2018 | Study protocol

Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Authors: Joseph Okebe, Joan Muela Ribera, Julie Balen, Fatou Jaiteh, Yoriko Masunaga, Davis Nwakanma, John Bradley, Shunmay Yeung, Koen Peeters Grietens, Umberto D’Alessandro

Published in: Trials | Issue 1/2018

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Abstract

Background

Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.

Methods/design

This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.

Discussion

Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.

Trial registration

Clinical trials.gov, NCT02878200. Registered on 25 August 2016. 
Appendix
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Literature
1.
Bousema T, Drakeley C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin Microbiol Rev. 2011;24:377–410.CrossRefPubMedPubMedCentral
2.
Global Malaria Programme. The role of mass drug administration, mass screening and treatment, and focal screening and treatment for malaria. Geneva: World Health Organization; 2015.
3.
Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev. 2013;12:CD008846.
4.
Kern SE, Tiono AB, Makanga M, Gbadoé AD, Premji Z, Gaye O, Sagara I, Ubben D, Cousin M, Oladiran F, et al. Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis. Malar J. 2011;10:210.CrossRefPubMedPubMedCentral
5.
Stresman GH, Kamanga A, Moono P, Hamapumbu H, Mharakurwa S, Kobayashi T, Moss WJ, Shiff C. A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province, Zambia. Malar J. 2010;9:265.PubMedPubMedCentral
6.
Sturrock HJ, Novotny JM, Kunene S, Dlamini S, Zulu Z, Cohen JM, Hsiang MS, Greenhouse B, Gosling RD. Reactive case detection for malaria elimination: real-life experience from an ongoing program in Swaziland. PLoS One. 2013;8:e63830.CrossRefPubMedPubMedCentral
7.
Littrell M, Sow GD, Ngom A, Ba M, Mboup BM, Dieye Y, Mutombo B, Earle D, Steketee RW. Case investigation and reactive case detection for malaria elimination in northern Senegal. Malar J. 2013;12:331.CrossRefPubMedPubMedCentral
8.
Hustedt J, Canavati SE, Rang C, Ashton RA, Khim N, Berne L, Kim S, Sovannaroth S, Ly P, Ménard D, et al. Reactive case-detection of malaria in Pailin Province, Western Cambodia: lessons from a year-long evaluation in a pre-elimination setting. Malar J. 2016;15:132.CrossRefPubMedPubMedCentral
9.
Searle KM, Hamapumbu H, Lubinda J, Shields TM, Pinchoff J, Kobayashi T, Stevenson JC, Bridges DJ, Larsen DA, Thuma PE, Moss WJ. Evaluation of the operational challenges in implementing reactive screen-and-treat and implications of reactive case detection strategies for malaria elimination in a region of low transmission in southern Zambia. Malar J. 2016;15:412.CrossRefPubMedPubMedCentral
10.
Smith Gueye C, Sanders KC, Galappaththy GN, Rundi C, Tobgay T, Sovannaroth S, Gao Q, Surya A, Thakur GD, Baquilod M, et al. Active case detection for malaria elimination: a survey among Asia Pacific countries. Malar J. 2013;12:358.CrossRefPubMedPubMedCentral
11.
Tiono AB, Ouedraogo A, Ogutu B, Diarra A, Coulibaly S, Gansane A, Sirima SB, O’Neil G, Mukhopadhyay A, Hamed K. A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malar J. 2013;12:79.CrossRefPubMedPubMedCentral
12.
Ceesay SJ, Casals-Pascual C, Erskine J, Anya SE, Duah NO, Fulford AJ, Sesay SS, Abubakar I, Dunyo S, Sey O, et al. Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis. Lancet. 2008;372:1545–54.CrossRefPubMedPubMedCentral
13.
van den Hoogen LL, Griffin JT, Cook J, Sepulveda N, Corran P, Conway DJ, Milligan P, Affara M, Allen SJ, Proietti C, et al. Serology describes a profile of declining malaria transmission in Farafenni, The Gambia. Malar J. 2015;14:416.CrossRefPubMedPubMedCentral
14.
15.
Tynan A, Atkinson JA, Toaliu H, Taleo G, Fitzgerald L, Whittaker M, Riley I, Schubert M, Vallely A. Community participation for malaria elimination in Tafea Province, Vanuatu: Part II. Social and cultural aspects of treatment-seeking behaviour. Malar J. 2011;10:204.CrossRefPubMedPubMedCentral
16.
Atkinson JAM, Fitzgerald L, Toaliu H, Taleo G, Tynan A, Whittaker M, Riley I, Vallely A. Community participation for malaria elimination in Tafea Province, Vanuatu: Part I. Maintaining motivation for prevention practices in the context of disappearing disease. Malar J. 2010;9:93.CrossRefPubMedPubMedCentral
17.
Kirby MJ, Ameh D, Bottomley C, Green C, Jawara M, Milligan PJ, Snell PC, Conway DJ, Lindsay SW. Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial. Lancet. 2009;374:998–1009.CrossRefPubMedPubMedCentral
18.
Oriero EC, Okebe J, Jacobs J, Van Geertruyden JP, Nwakanma D, D’Alessandro U. Diagnostic performance of a novel loop-mediated isothermal amplification (LAMP) assay targeting the apicoplast genome for malaria diagnosis in a field setting in sub-Saharan Africa. Malar J. 2015;14:396.CrossRefPubMedPubMedCentral
19.
World Health Organization (WHO). Guidelines for the treatment of malaria. 3rd ed. Geneva: WHO; 2015.
20.
Mwesigwa J, Okebe J, Affara M, Di Tanna GL, Nwakanma D, Janha O, Opondo K, Grietens KP, Achan J, D’Alessandro U. On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey. Malar J. 2015;14:314.CrossRefPubMedPubMedCentral
21.
Pinder M, Jawara M, Jarju LB, Salami K, Jeffries D, Adiamoh M, Bojang K, Correa S, Kandeh B, Kaur H, et al. Efficacy of indoor residual spraying with dichlorodiphenyltrichloroethane against malaria in Gambian communities with high usage of long-lasting insecticidal mosquito nets: a cluster-randomised controlled trial. Lancet. 2015;385:1436–46.CrossRefPubMed
22.
23.
24.
Hofmann N, Mwingira F, Shekalaghe S, Robinson LJ, Mueller I, Felger I. Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targets. PLoS Med. 2015;12:e1001788.CrossRefPubMedPubMedCentral
25.
Daniels R, Ndiaye D, Wall M, McKinney J, Sene PD, Sabeti PC, Volkman SK, Mboup S, Wirth DF. Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrob Agents Chemother. 2012;56:2976–86.CrossRefPubMedPubMedCentral
26.
Lindblade KA, Steinhardt L, Samuels A, Kachur SP, Slutsker L. The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther. 2013;11:623–39.CrossRefPubMed
27.
Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, et al. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015;93:125–34.CrossRefPubMedPubMedCentral
28.
von Seidlein L, Dondorp A. Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance. Expert Rev Anti Infect Ther. 2015;13:715–30.CrossRefPubMed
29.
Strachan CE, Kana M, Martin S, Dada J, Wandera N, Marasciulo M, Counihan H, Kolawole M, Babale T, Hamade P, et al. The use of formative research to inform the design of a seasonal malaria chemoprevention intervention in northern Nigeria. Malar J. 2016;15:474.CrossRefPubMedPubMedCentral
30.
Tine RC, Ndiaye P, Ndour CT, Faye B, Ndiaye JL, Sylla K, Ndiaye M, Cisse B, Sow D, Magnussen P, et al. Acceptability by community health workers in Senegal of combining community case management of malaria and seasonal malaria chemoprevention. Malar J. 2013;12:467.CrossRefPubMedPubMedCentral
31.
Kaneko A, Taleo G, Kalkoa M, Yamar S, Kobayakawa T, Bjorkman A. Malaria eradication on islands. Lancet. 2000;356:1560–4.CrossRefPubMed
32.
Dial NJ, Ceesay SJ, Gosling RD, D’Alessandro U, Baltzell KA. A qualitative study to assess community barriers to malaria mass drug administration trials in The Gambia. Malar J. 2014;13:47.CrossRefPubMedPubMedCentral
33.
Dierickx S, Gryseels C, Mwesigwa J, O’Neill S, Bannister-Tyrell M, Ronse M, Jaiteh F, Gerrets R, D’Alessandro U, Grietens KP. Factors associated with non-participation and non-adherence in directly observed mass drug administration for malaria in The Gambia. PLoS One. 2016;11:e0148627.CrossRefPubMedPubMedCentral
34.
Rutherford ME, Dockerty JD, Jasseh M, Howie SR, Herbison P, Jeffries DJ, Leach M, Stevens W, Mulholland K, Adegbola RA, Hill PC. Access to health care and mortality of children under 5 years of age in The Gambia: a case-control study. Bull World Health Organ. 2009;87:216–24.CrossRefPubMedPubMedCentral
Metadata
Title
Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial
Authors
Joseph Okebe
Joan Muela Ribera
Julie Balen
Fatou Jaiteh
Yoriko Masunaga
Davis Nwakanma
John Bradley
Shunmay Yeung
Koen Peeters Grietens
Umberto D’Alessandro
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Trials / Issue 1/2018
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-018-2506-x

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