Skip to main content
Top
Published in: Trials 1/2016

Open Access 01-12-2016 | Study protocol

Mass mosquito trapping for malaria control in western Kenya: study protocol for a stepped wedge cluster-randomised trial

Authors: Alexandra Hiscox, Tobias Homan, Collins K. Mweresa, Nicolas Maire, Aurelio Di Pasquale, Daniel Masiga, Prisca A. Oria, Jane Alaii, Cees Leeuwis, Wolfgang R. Mukabana, Willem Takken, Thomas A. Smith

Published in: Trials | Issue 1/2016

Login to get access

Abstract

Background

Increasing levels of insecticide resistance as well as outdoor, residual transmission of malaria threaten the efficacy of existing vector control tools used against malaria mosquitoes. The development of odour-baited mosquito traps has led to the possibility of controlling malaria through mass trapping of malaria vectors. Through daily removal trapping against a background of continued bed net use it is anticipated that vector populations could be suppressed to a level where continued transmission of malaria will no longer be possible.

Methods/design

A stepped wedge cluster-randomised trial design was used for the implementation of mass mosquito trapping on Rusinga Island, western Kenya (the SolarMal project). Over the course of 2 years (2013–2015) all households on the island were provided with a solar-powered mosquito trapping system. A continuous health and demographic surveillance system combined with parasitological surveys three times a year, successive rounds of mosquito monitoring and regular sociological studies allowed measurement of intervention outcomes before, during and at completion of the rollout of traps. Data collection continued after achieving mass coverage with traps in order to estimate the longer term effectiveness of this novel intervention. Solar energy was exploited to provide electric light and mobile phone charging for each household, and the impacts of these immediate tangible benefits upon acceptability of and adherence to the use of the intervention are being measured.

Discussion

This study will be the first to evaluate whether the principle of solar-powered mass mosquito trapping could be an effective tool for elimination of malaria. If proven to be effective, this novel approach to malaria control would be a valuable addition to the existing strategies of long-lasting insecticide-treated nets and case management. Sociological studies provide a knowledge base for understanding the usage of this novel tool.

Trial registration

Trialregister.nl: NTR3496 – SolarMal. Registered on 20 June 2012.
Appendix
Available only for authorised users
Literature
4.
go back to reference World Health Organization. World Malaria Report 2014. Geneva: World Health Organization; 2015. World Health Organization. World Malaria Report 2014. Geneva: World Health Organization; 2015.
6.
go back to reference World Health Organization RBMP. Action and investment to defeat malaria 2016-2030. For a malaria-free world. Geneva: WHO; 2015. World Health Organization RBMP. Action and investment to defeat malaria 2016-2030. For a malaria-free world. Geneva: WHO; 2015.
7.
go back to reference Verhulst NO, Qiu YT, Beijleveld H, Maliepaard C, Knights D, Schulz S, et al. Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One. 2011;6(12):e28991.CrossRefPubMedPubMedCentral Verhulst NO, Qiu YT, Beijleveld H, Maliepaard C, Knights D, Schulz S, et al. Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One. 2011;6(12):e28991.CrossRefPubMedPubMedCentral
8.
go back to reference Okumu FO, Killeen GF, Ogoma S, Biswaro L, Smallegange RC, Mbeyela E, et al. Development and field evaluation of a synthetic mosquito lure that is more attractive than humans. PLoS One. 2010;5(1):e8951.CrossRefPubMedPubMedCentral Okumu FO, Killeen GF, Ogoma S, Biswaro L, Smallegange RC, Mbeyela E, et al. Development and field evaluation of a synthetic mosquito lure that is more attractive than humans. PLoS One. 2010;5(1):e8951.CrossRefPubMedPubMedCentral
9.
go back to reference Mukabana WR, Mweresa CK, Otieno B, Omusula P, Smallegange RC, van Loon JJA, et al. A novel synthetic odorant blend for trapping of malaria and other African mosquito species. J Chem Ecol. 2012;38(3):235–44.CrossRefPubMedPubMedCentral Mukabana WR, Mweresa CK, Otieno B, Omusula P, Smallegange RC, van Loon JJA, et al. A novel synthetic odorant blend for trapping of malaria and other African mosquito species. J Chem Ecol. 2012;38(3):235–44.CrossRefPubMedPubMedCentral
14.
go back to reference Matowo NS, Moore J, Mapua S, Madumla EP, Moshi IR, Kaindoa EW, et al. Using a new odour-baited device to explore options for luring and killing outdoor-biting malaria vectors: a report on design and field evaluation of the Mosquito Landing Box. Parasite Vector. 2013;6:137.CrossRef Matowo NS, Moore J, Mapua S, Madumla EP, Moshi IR, Kaindoa EW, et al. Using a new odour-baited device to explore options for luring and killing outdoor-biting malaria vectors: a report on design and field evaluation of the Mosquito Landing Box. Parasite Vector. 2013;6:137.CrossRef
16.
go back to reference Okumu FO, Govella NJ, Moore SJ, Chitnis N, Killeen GF. Potential benefits, limitations and target product-profiles of odor-baited mosquito traps for malaria control in Africa. PLoS One. 2010;5(7). doi:ARTN e11573 DOI 10.1371/journal.pone.0011573. Okumu FO, Govella NJ, Moore SJ, Chitnis N, Killeen GF. Potential benefits, limitations and target product-profiles of odor-baited mosquito traps for malaria control in Africa. PLoS One. 2010;5(7). doi:ARTN e11573 DOI 10.​1371/​journal.​pone.​0011573.
19.
go back to reference ter Kuile FO, Terlouw DJ, Phillips-Howard PA, Hawley WA, Friedman JF, Kolczak MS, et al. Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey. Am J Trop Med Hyg. 2003;68(4 Suppl):100–7.PubMed ter Kuile FO, Terlouw DJ, Phillips-Howard PA, Hawley WA, Friedman JF, Kolczak MS, et al. Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey. Am J Trop Med Hyg. 2003;68(4 Suppl):100–7.PubMed
20.
go back to reference Phillips-Howard PA, Nahlen BL, Kolczak MS, Hightower AW, ter Kuile FO, Alaii JA, et al. Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya. Am J Trop Med Hyg. 2003;68(4 Suppl):23–9.PubMed Phillips-Howard PA, Nahlen BL, Kolczak MS, Hightower AW, ter Kuile FO, Alaii JA, et al. Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya. Am J Trop Med Hyg. 2003;68(4 Suppl):23–9.PubMed
21.
go back to reference Hawley WA, Phillips-Howard PA, ter Kuile FO, Terlouw DJ, Vulule JM, Ombok M, et al. Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya. Am J Trop Med Hyg. 2003;68(4 Suppl):121–7.PubMed Hawley WA, Phillips-Howard PA, ter Kuile FO, Terlouw DJ, Vulule JM, Ombok M, et al. Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya. Am J Trop Med Hyg. 2003;68(4 Suppl):121–7.PubMed
23.
go back to reference Idris ZM, Chim WC, Chang SD, Masatsugu K, Isao T, Ahmediin O, et al. Geographic and seasonal variation in malaria prevalance on islands in Lake Victoria (western Kenya): results from three cross sectional studies. Malar J. 2014;13 Suppl 1:61. doi:10.1186/1475-2875-13-S1-P61.CrossRef Idris ZM, Chim WC, Chang SD, Masatsugu K, Isao T, Ahmediin O, et al. Geographic and seasonal variation in malaria prevalance on islands in Lake Victoria (western Kenya): results from three cross sectional studies. Malar J. 2014;13 Suppl 1:61. doi:10.​1186/​1475-2875-13-S1-P61.CrossRef
24.
go back to reference Oria PA, Hiscox A, Alaii J, Ayugi M, Mukabana WR, Takken W, et al. Tracking the mutual shaping of the technical and social dimensions of solar-powered mosquito trapping systems (SMoTS) for malaria control on Rusinga Island, western Kenya. Parasit Vector. 2014;7:523. doi:10.1186/S13071-014-0523-5.CrossRef Oria PA, Hiscox A, Alaii J, Ayugi M, Mukabana WR, Takken W, et al. Tracking the mutual shaping of the technical and social dimensions of solar-powered mosquito trapping systems (SMoTS) for malaria control on Rusinga Island, western Kenya. Parasit Vector. 2014;7:523. doi:10.​1186/​S13071-014-0523-5.CrossRef
26.
go back to reference Beier JC, Oster CN, Onyango FK, Bales JD, Sherwood JA, Perkins PV, et al. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am J Trop Med Hyg. 1994;50(5):529–36.PubMed Beier JC, Oster CN, Onyango FK, Bales JD, Sherwood JA, Perkins PV, et al. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am J Trop Med Hyg. 1994;50(5):529–36.PubMed
29.
go back to reference Gillies MT, De Meillon B. The Anophelinae of Africa south of the Sahara: Publications of the South African Institute for Medical Research. 1968. Gillies MT, De Meillon B. The Anophelinae of Africa south of the Sahara: Publications of the South African Institute for Medical Research. 1968.
30.
go back to reference Gillies MT, Wilkes TJ. The range of attraction of single baits for some West African mosquitoes. Bull Entomol Res. 1970;60:225–35.CrossRefPubMed Gillies MT, Wilkes TJ. The range of attraction of single baits for some West African mosquitoes. Bull Entomol Res. 1970;60:225–35.CrossRefPubMed
31.
go back to reference Oria PA, Alaii J, Ayugi M, Takken W, Leeuwis C. Combining malaria control with house electrification: adherence to recommended behaviours for proper deployment of solar-powered mosquito trapping systems, Rusinga Island, western Kenya. Trop Med Int Health. 2015;20(8):1048–56. doi:10.1111/tmi.12514.CrossRefPubMed Oria PA, Alaii J, Ayugi M, Takken W, Leeuwis C. Combining malaria control with house electrification: adherence to recommended behaviours for proper deployment of solar-powered mosquito trapping systems, Rusinga Island, western Kenya. Trop Med Int Health. 2015;20(8):1048–56. doi:10.​1111/​tmi.​12514.CrossRefPubMed
32.
33.
go back to reference Silkey M, Homan T, Maire N, Hiscox A, Mukabana WR, Takken W, Smith TA. Design of trials for interrupting the transmission of endemic pathogens. Trials. 2016;17:278.CrossRefPubMedPubMedCentral Silkey M, Homan T, Maire N, Hiscox A, Mukabana WR, Takken W, Smith TA. Design of trials for interrupting the transmission of endemic pathogens. Trials. 2016;17:278.CrossRefPubMedPubMedCentral
34.
go back to reference Homan T, Di Pasquale A, Kiche I, Onoka K, Hiscox A, Mweresa CK, et al. Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya. BMC Res Notes. 2015;8(1):397.CrossRefPubMedPubMedCentral Homan T, Di Pasquale A, Kiche I, Onoka K, Hiscox A, Mweresa CK, et al. Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya. BMC Res Notes. 2015;8(1):397.CrossRefPubMedPubMedCentral
37.
go back to reference Gillies MT, Coetzee M. A supplement to the Anophelinae of Africa south of the Sahara (Afrotropical region). Publ S Afr Inst Med Res. 1987;55:1–143. Gillies MT, Coetzee M. A supplement to the Anophelinae of Africa south of the Sahara (Afrotropical region). Publ S Afr Inst Med Res. 1987;55:1–143.
38.
go back to reference Koekemoer LL, Kamau L, Hunt RH, Coetzee M. A cocktail polymerase chain reaction assay to identify members of the Anopheles funestus (Diptera: Culicidae) group. Am J Trop Med Hyg. 2002;66(6):804–11.PubMed Koekemoer LL, Kamau L, Hunt RH, Coetzee M. A cocktail polymerase chain reaction assay to identify members of the Anopheles funestus (Diptera: Culicidae) group. Am J Trop Med Hyg. 2002;66(6):804–11.PubMed
39.
go back to reference Scott JA, Brogdon WG, Collins FH. Identification of single specimens of the Anopheles gambiae complex by the polymerase chain-reaction. Am J Trop Med Hyg. 1993;49(4):520–9.PubMed Scott JA, Brogdon WG, Collins FH. Identification of single specimens of the Anopheles gambiae complex by the polymerase chain-reaction. Am J Trop Med Hyg. 1993;49(4):520–9.PubMed
40.
go back to reference Hartung C, Lerer A, Anokwa Y, Tseng C, Brunette W, Borriello G. Open data kit: tools to build information services for developing regions. Proc 4th ACM/IEEE Int'l Conf Information and Communication Technologies and Development, vol. 2010. 2010. p. 1–11. Hartung C, Lerer A, Anokwa Y, Tseng C, Brunette W, Borriello G. Open data kit: tools to build information services for developing regions. Proc 4th ACM/IEEE Int'l Conf Information and Communication Technologies and Development, vol. 2010. 2010. p. 1–11.
41.
go back to reference Asangansi IMB, Meremikwu M, et al. Improving the routine HMIS in Nigeria through mobile technology for community data collection. JHIDC. 2013;7:1. Asangansi IMB, Meremikwu M, et al. Improving the routine HMIS in Nigeria through mobile technology for community data collection. JHIDC. 2013;7:1.
Metadata
Title
Mass mosquito trapping for malaria control in western Kenya: study protocol for a stepped wedge cluster-randomised trial
Authors
Alexandra Hiscox
Tobias Homan
Collins K. Mweresa
Nicolas Maire
Aurelio Di Pasquale
Daniel Masiga
Prisca A. Oria
Jane Alaii
Cees Leeuwis
Wolfgang R. Mukabana
Willem Takken
Thomas A. Smith
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Trials / Issue 1/2016
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-016-1469-z

Other articles of this Issue 1/2016

Trials 1/2016 Go to the issue