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Trials
Published in: Trials 1/2015

Open Access 01-12-2015 | Research

Quality of randomized controlled trials reporting in the treatment of melasma conducted in China

Authors: Zhiwei Chen, Yuchi Chen, Jingchun Zeng, Yang Wang, Teng Ye, Qiaochu Zhou, Xiaojing Du, Wenting Su, Zhishan Ding

Published in: Trials | Issue 1/2015

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Abstract

Background

There is no existing report on the quality of randomized controlled trials (RCTs) of melasma treatment currently conducted in China. This study aims to assess the quality of RCT- reporting in the treatment of melasma conducted in China.

Methods

Several databases were searched from their inception through to August 2014. In order to rate the report quality, we scored 1 for the item if it was reported in CONSORT 2010 and 0 for the item if it was not definitely stated or was not clear. For overall quality score (OQS), 13 items were scored and calculated with a range of 0 to 13. Five items (‘randomization’, ‘allocation concealment’, ‘blinding’, ‘baseline characteristics’ and ‘intention-to-treat (ITT) analysis’) were scored and a key methodological index score (MIS) was calculated with a range of 0 to 5 for each trial.

Results

A total of 246 relevant RCTs were included in the final analysis. The median OQS was 7, with a minimum of 4 and a maximum of 11. Some items’ information was insufficient, especially in the categories of ‘trial design’, ‘sample size’, ‘recruitment’ and ‘ancillary analyses’ with a positive rate of less than 20%. The median MIS was 1 with a minimum of 0 and a maximum of 3. Some items’ reporting was poor, especially in the categories of ‘randomization’, ‘allocation concealment and implementation’, ‘blinding’ and ‘ITT analysis’ with a positive rate of less than 10%. The mean OQS increased by about 0.52 for manuscripts published in the period of 5-year increments (95% CI: 0.32 to 0.72; P < 0.001). With regard to the MIS, no variable was statistically significant in the ordinal regression model.

Conclusion

The reporting quality of RCTs in the treatment of melasma conducted in China is not satisfactory especially in key methodological items. Reporting of RCTs in this field should meet and keep up with the standards of the CONSORT statement.
Appendix
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Metadata
Title
Quality of randomized controlled trials reporting in the treatment of melasma conducted in China
Authors
Zhiwei Chen
Yuchi Chen
Jingchun Zeng
Yang Wang
Teng Ye
Qiaochu Zhou
Xiaojing Du
Wenting Su
Zhishan Ding
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue 1/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-015-0677-2

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