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Open Access 01-12-2022 | Septicemia | Comment

Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?

Authors: Christian Stoppe, Jean-Charles Preiser, Daniel de Backer, Gunnar Elke

Published in: Critical Care | Issue 1/2022

Excerpt

The recent results of the lessening organ dysfunction with vitamin C (LOVIT) randomized controlled trial (RCT) have challenged the potentially beneficial role and brought concerns on the safety of high-dose vitamin C in patients with sepsis. Septic patients admitted to the intensive care unit (ICU) received either high-dose vitamin C or placebo. As opposed to placebo, vitamin C was associated with an increased occurrence of the primary endpoint (persistent organ dysfunction plus death) [1]. While these results may suggest the end of the vitamin C story, several aspects suggest that LOVIT is just one piece of the puzzle and that the baby should not be thrown out with the bathwater. …

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Title: Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?
Authors: Christian Stoppe
Jean-Charles Preiser
Daniel de Backer
Gunnar Elke
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Published in: Critical Care / Issue 1/2022
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-022-04106-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

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