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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Septicemia | Research Letter

Early sepsis identification following cytoreductive surgery for peritoneal malignancy

Authors: Darius Cameron Wilson, Danylo Yershov, Chandrakumaran Kandiah, Nicholas Cortes, Kirsty Gordon, Kordo Saeed

Published in: Critical Care | Issue 1/2020

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Excerpt

Cytoreductive surgery for peritoneal malignancy often involves extensive tissue resection, a prolonged operating time, and a significant post-operative systemic inflammatory response (SIRS) [1]. The development of a subsequent post-surgical infection constitutes a common cause of morbidity and mortality, with intra-abdominal infections, in particular, resulting in high mortality rates due to the progression towards tertiary peritonitis and multiple organ dysfunction [2]. The relatively high incidence of infection development, coupled with the immense systemic inflammatory response generated following surgery, makes an early identification of infection problematic and may result in the suboptimal administration of antibiotics. …
Literature
1.
Saeed K, Dale AP, Leung E, Cusack T, Mohamed F, Lockyer G, et al. Procalcitonin levels predict infectious complications and response to treatment in patients undergoing cytoreductive surgery for peritoneal malignancy. Eur J Surg Oncol. 2016;42(2):234–43.CrossRef
2.
Evans HL, Raymond DP, Pelletier SJ, Crabtree TD, Pruett TL, Sawyer RG. Diagnosis of intra-abdominal infection in the critically ill patient. Curr Opin Crit Care. 2001;7(2):117–21.CrossRef
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Meisner M, Tschaikowsky K, Hutzler A, Schick C, Schuttler J. Post-operative plasma concentrations of procalcitonin after different types of surgery. Intensive Care Med. 1998;28:680–4.CrossRef
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Gille J, Ostermann H, Dragu A, Sablotzki A. MR-proADM: a new biomarker for early diagnosis of sepsis in burned patients. J Burn Care Res. 2017;38:290–8.CrossRef
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Elke G, Bloos F, Wilson DC, et al. The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis--a secondary analysis of a large randomised controlled trial. Crit Care. 2018;22(1):79.CrossRef
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Elke G, Bloos F, Wilson DC, Meybohm P. Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores. Crit Care. 2018;22(1):147.CrossRef
Metadata
Title
Early sepsis identification following cytoreductive surgery for peritoneal malignancy
Authors
Darius Cameron Wilson
Danylo Yershov
Chandrakumaran Kandiah
Nicholas Cortes
Kirsty Gordon
Kordo Saeed
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-2831-9

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