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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | ECMO | Editorial

How I approach membrane lung dysfunction in patients receiving ECMO

Authors: Bishoy Zakhary, Leen Vercaemst, Phillip Mason, Marta V. Antonini, Roberto Lorusso, Daniel Brodie

Published in: Critical Care | Issue 1/2020

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Excerpt

With improvements in circuit technology and expanding supportive evidence, extracorporeal membrane oxygenation (ECMO) use has grown rapidly over the past decade [1]. Advances in pump and membrane lung (ML) design have led to simpler and more efficient circuits. Circuit-related complications, however, remain frequent and associated with considerable morbidity [2]. …
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Literature
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Brodie D, Slutsky AS, Combes A. Extracorporeal life support for adults with respiratory failure and related indications: a review. JAMA. 2019;322(6):557–68.CrossRef
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Dornia C, Philipp A, Bauer S, Lubnow M, Muller T, Lehle K, et al. Analysis of thrombotic deposits in extracorporeal membrane oxygenators by multidetector computed tomography. ASAIO J. 2014;60(6):652–6.CrossRef
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Doyle AJ, Hunt BJ. Current understanding of how extracorporeal membrane oxygenators activate haemostasis and other blood components. Front Med (Lausanne). 2018;5:352.CrossRef
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Maul TM, Massicotte MP, Wearden PD. ECMO biocompatibility: surface coatings, anticoagulation, and coagulation monitoring. In: Firstenberg MS, editor. Extracorporeal Membrane Oxygenation: Advances in Therapy. Croatia: IntechOpen; 2016. p. 30–5.
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Lubnow M, Philipp A, Foltan M, Bull Enger T, Lunz D, Bein T, et al. Technical complications during veno-venous extracorporeal membrane oxygenation and their relevance predicting a system-exchange–retrospective analysis of 265 cases. PLoS ONE. 2014;9(12):e112316.CrossRef
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Hastings SM, Deshpande SR, Wagoner S, Maher K, Ku DN. Thrombosis in centrifugal pumps: location and composition in clinical and in vitro circuits. Int J Artif Organs. 2016;39(4):200–4.CrossRef
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Lehle K, Philipp A, Gleich O, Holzamer A, Muller T, Bein T, et al. Efficiency in extracorporeal membrane oxygenation-cellular deposits on polymethylpentene membranes increase resistance to blood flow and reduce gas exchange capacity. ASAIO J. 2008;54(6):612–7.CrossRef
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Epis F, Belliato M. Oxygenator performance and artificial-native lung interaction. J Thorac Dis. 2018;10(Suppl 5):S596–605.CrossRef
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Zakhary B, Sheldrake J, Pellegrino V. Extracorporeal membrane oxygenation and V/Q ratios: an ex vivo analysis of CO2 clearance within the Maquet Quadrox-iD oxygenator. Perfusion. 2020;35(1):29–33.CrossRef
Metadata
Title
How I approach membrane lung dysfunction in patients receiving ECMO
Authors
Bishoy Zakhary
Leen Vercaemst
Phillip Mason
Marta V. Antonini
Roberto Lorusso
Daniel Brodie
Publication date
01-12-2020
Publisher
BioMed Central
Keywords
ECMO
ECMO
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03388-2

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