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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Critical Care
Literature
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Santamarina MG, Boisier D, Contreras R, Baque M, Volpacchio M, Beddings I. COVID-19: a hypothesis regarding the ventilation-perfusion mismatch. Crit Care. 2020;24(1):395.CrossRef
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Vellinga NA, Veenstra G, Scorcella C, Koopmans M, van Roon EN, Ince C, et al. Effects of ketanserin on microcirculatory alterations in septic shock: an open-label pilot study. J Crit Care. 2015;30(6):1156–62.CrossRef
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Han TH, Qamirani E, Nelson AG, Hyduke DR, Chaudhuri G, Kuo L, et al. Regulation of nitric oxide consumption by hypoxic red blood cells. Proc Natl Acad Sci U S A. 2003;100(21):12504–9.CrossRef
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Meuleman TR, Hill DC, Port JD, Stanley TH, Pace NL, Mohammad SF. Ketanserin prevents platelet aggregation and endotoxin-induced pulmonary vasoconstriction. Crit Care Med. 1983;11(8):606–11.CrossRef
Metadata
Title
Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?
Authors
M. Kuindersma
P. E. Spronk
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03257-y

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