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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | SARS-CoV-2 | Research Letter

Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome

Authors: Luis Chiscano-Camón, Juan Carlos Ruiz-Rodriguez, Adolf Ruiz-Sanmartin, Oriol Roca, Ricard Ferrer

Published in: Critical Care | Issue 1/2020

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Excerpt

Vitamin C is an antioxidant with anti-inflammatory and immune-supportive properties. Its levels are decreased in patients with sepsis-related acute respiratory distress syndrome (ARDS). Moreover, a significant number of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease developed ARDS [1]. Therefore, we hypothesized that ARDS coronavirus disease 2019 (COVID-19) patients may present vitamin C deficiency. …
Literature
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ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutksy AS. Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012;307(23):2526–33.
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Carr A. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care. 2020;24:133.CrossRef
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Atherton JG, Kratzing CC, Fisher A. The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus. Arch Viro. 1978;56:195–9.CrossRef
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Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically III surgical patients. Ann Surg. 2002;236:814–22.CrossRef
Metadata
Title
Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome
Authors
Luis Chiscano-Camón
Juan Carlos Ruiz-Rodriguez
Adolf Ruiz-Sanmartin
Oriol Roca
Ricard Ferrer
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03249-y

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