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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | SARS-CoV-2 | Review

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Authors: Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González, Franco Díaz

Published in: Critical Care | Issue 1/2020

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Abstract

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.
In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
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Metadata
Title
A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
Authors
Pablo Cruces
Jaime Retamal
Daniel E. Hurtado
Benjamín Erranz
Pablo Iturrieta
Carlos González
Franco Díaz
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03197-7

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