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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Septicemia | Letter

Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

Published in: Critical Care | Issue 1/2020

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Excerpt

Disease is a complex interaction between disease-causing agent, host, and the environment. About 90–95% of the public that test positive for coronavirus recover; hence, most of us have inbuilt host response that creates a life-sustaining relationship with coronavirus. Shen and colleagues have used plasma from survivors to study the amplification of host response in severe Covid-19 patients [1]. Modern medicine has been documenting the evidence behind the ancient wisdom—“home of immunity is the gut microbiome” [2]. Hence, we address the scope of understanding host response and immunity during this time of global emergency. …
Literature
1.
Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, Wang F, Li D, Yang M, Xing L, Wei J. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020;323(16):1582–9.
2.
Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell. 2018;33(4):570–80.CrossRef
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Brandt LJ. Fecal transplantation for the treatment of Clostridium difficile infection. Gastroenterol Hepatol (N Y). 2012;8(3):191–4.
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Wei Y, Yang J, Wang J, Yang Y, Huang J, Gong H, Cui H, Chen D. Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis. Crit Care. 2016;20(1):332.CrossRef
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Ianiro G, Murri R, Sciumè GD, et al. Incidence of bloodstream infections, length of hospital stay, and survival in patients with recurrent Clostridioides difficile infection treated with fecal microbiota transplantation or antibiotics: a prospective cohort study. Ann Intern Med. 2019;171:695–702.CrossRef
Metadata
Title
Compassionate use of others’ immunity — understanding gut microbiome in Covid-19
Publication date
01-12-2020
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03043-w

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