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Open Access 01-12-2020 | SARS-CoV-2 | Research Letter

Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients

Authors: Zhiyong Wu, Rui Hu, Cuizhen Zhang, Wei Ren, Anfeng Yu, Xiaoyang Zhou

Published in: Critical Care | Issue 1/2020

Excerpt

Little is known about the mechanism of coronavirus disease 2019 (COVID-19)-induced critical illness and death. The host infection mediated by SARS-CoV-2 is mainly relied on ACE2 receptor. There is still a lack of clinical data about the effects of interaction of ACE2 and SARS-CoV-2 on RAS system and disease progression. We investigated the plasma angiotensin II (Ang II) and renin levels in 82 non-hypertensive patients (42 mild cases, 25 severe cases, and 15 critically ill cases) infected by SARS-CoV-2 and 12 critically ill patients not infected by SARS-CoV-2 serving as control. …

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Title: Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients
Authors: Zhiyong Wu
Rui Hu
Cuizhen Zhang
Wei Ren
Anfeng Yu
Xiaoyang Zhou
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: SARS-CoV-2
COVID-19
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-03015-0

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Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients

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