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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Critical Care
Literature
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Lanspa MJ, Peltan ID, Jacobs JR, Sorensen JS, Carpenter L, Ferraro JP, Brown SM, Berry JG, Srivastava R, Grissom CK. Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS. Crit Care. 2019;23(1):424.CrossRef
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Writing Group for the PI, Simonis FD, Serpa Neto A, Binnekade JM, Braber A, KCM B, Determann RM, Goekoop GJ, Heidt J, Horn J, et al. Effect of a low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS: a randomized clinical trial. JAMA. 2018;320(18):1872–80.CrossRef
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Mireles-Cabodevila E, Chatburn RL. Work of breathing in adaptive pressure control continuous mandatory ventilation. Respir Care. 2009;54(11):1467–72.PubMed
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Bertoni M, Telias I, Urner M, Long M, Del Sorbo L, Fan E, Sinderby C, Beck J, Liu L, Qiu H, et al. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23(1):346.CrossRef
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Schuhlen H. Pre-specified vs. post-hoc subgroup analyses: are we wiser before or after a trial has been performed? Eur Heart J. 2014;35(31):2055–7.CrossRef
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Schmidt MFS, Amaral A, Fan E, Rubenfeld GD. Driving pressure and hospital mortality in patients without ARDS: a cohort study. Chest. 2018;153(1):46–54.CrossRef
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Metadata
Title
Why driving pressure is not associated with the mortality in non-ARDS patients?
Authors
Huixue Huang
Hangyong He
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-02845-2

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