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Open Access 01-12-2019 | Care | Research Letter

Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial

Authors: Wanessa Teixeira Bellissimo-Rodrigues, Mayra Gonçalves Menegueti, Leandro Dorigan de Macedo, Anibal Basile-Filho, Roberto Martinez, Fernando Bellissimo-Rodrigues

Published in: Critical Care | Issue 1/2019

Excerpt

Chlorhexidine (CHX) oral application has been widely used for preventing respiratory infections among critically ill patients, despite controversial effectiveness and the suspicion that it could enhance their mortality [1‐3]. The physiopathology behind this association is poorly understood [2, 3]. Our objective was to reassess data from a clinical trial searching for potential pathways for the CHX-associated mortality [4, 5]. …

Klompas M, Speck K, Howell MD, Greene LR, Berenholtz SM. Reappraisal of routine oral care with chlorhexidine gluconate for patients receiving mechanical ventilation: systematic review and meta-analysis. JAMA Intern Med. 2014;174:751–61.CrossRef

Price R, MacLennan G, Glen J, SuDDICU Collaboration. Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis. BMJ. 2014;348:g2197.CrossRef

Deschepper M, Waegeman W, Eeckloo K, Vogelaers D, Blot S. Effects of chlorhexidine gluconate oral care on hospital mortality: a hospital-wide, observational cohort study. Intensive Care Med. 2018;44:1017–26.CrossRef

Bellissimo-Rodrigues WT, Menegueti MG, Gaspar GG, Nicolini EA, Auxiliadora-Martins M, Basile-Filho A, et al. Effectiveness of a dental care intervention in the prevention of lower respiratory tract nosocomial infections among intensive care patients: a randomized clinical trial. Infect Control Hosp Epidemiol. 2014;35:1342–8.CrossRef

Bellissimo-Rodrigues WT, Menegueti MG, Gaspar GG, de Souza HCC, Auxiliadora-Martins M, Basile-Filho A, et al. Is it necessary to have a dentist within an intensive care unit team? Report of a randomised clinical trial. Int Dent J. 2018;68:420–7.CrossRef

Plantinga NL, Wittekamp BHJ, Leleu K, Depuydt P, Van den Abeele A-M, Brun-Buisson C, et al. Oral mucosal adverse events with chlorhexidine 2% mouthwash in ICU. Intensive Care Med. 2016;42:620–1.CrossRef

Title: Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial
Authors: Wanessa Teixeira Bellissimo-Rodrigues
Mayra Gonçalves Menegueti
Leandro Dorigan de Macedo
Anibal Basile-Filho
Roberto Martinez
Fernando Bellissimo-Rodrigues
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Care
Published in: Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-019-2664-6

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Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

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