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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Editorial

Harmful effects of mechanical ventilation on neurocognitive functions

Authors: Federico Bilotta, Giovanni Giordano, Paola Giuseppina Sergi, Francesco Pugliese

Published in: Critical Care | Issue 1/2019

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Excerpt

Whether mechanical ventilation (MV) induces neurotoxicity that can trigger or accelerate chronic cognitive disorders is controversial [1, 2]. The relationship between MV and neurocognitive impairment—that persisted at hospital discharge and at 1-year follow up—was first reported in 1999 in MV-treated ARDS patients [3]. Since then, several preclinical and clinical studies have investigated the mechanisms, localization, and timing of brain damage induced by MV and possible preventive/therapeutic strategies. …
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Bickenbach J, Zoremba N, Fries M, et al. Low tidal volume ventilation in a porcine model of acute lung injury improves cerebral tissue oxygenation. Anesth Analg. 2009;109(3):847–55.CrossRef
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Metadata
Title
Harmful effects of mechanical ventilation on neurocognitive functions
Authors
Federico Bilotta
Giovanni Giordano
Paola Giuseppina Sergi
Francesco Pugliese
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2546-y

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