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Open Access 01-12-2019 | Antibiotic | Letter

Quality and quantity of sample size is crucial in clinical studies to exclude association: antimicrobial exposure and the risk of delirium in critically ill patients

Authors: Rashid Nadeem, Zainab Ameer Obeida, Sahish Kamat, Ahmed Nazir Elsousi

Published in: Critical Care | Issue 1/2019

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To the Editor: …

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Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL. Cefepime-induced neurotoxicity: A systematic review. Crit Care. 2017;21(1):276.CrossRef

Grahl JJ, Stollings JL, Rakhit S, et al. Antimicrobial exposure and the risk of delirium in critically ill patients. Crit Care Lond Engl. 2018;22(1):337. https://doi.org/10.1186/s13054-018-2262-z.CrossRef

Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. JAMA. 2007;298(22):2644–53. https://doi.org/10.1001/jama.298.22.2644.CrossRefPubMed

Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306. https://doi.org/10.1097/CCM.0b013e3182783b72.CrossRefPubMed

Marra A, Ely EW, Pandharipande PP, Patel MB. The ABCDEF bundle in critical care. Crit Care Clin. 2017;33(2):225–43. https://doi.org/10.1016/j.ccc.2016.12.005.CrossRefPubMedPubMedCentral

Jakob SM, Ruokonen E, Grounds RM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: Two randomized controlled trials. JAMA. 2012;307(11):1151–60. https://doi.org/10.1001/jama.2012.304.CrossRefPubMed

Title: Quality and quantity of sample size is crucial in clinical studies to exclude association: antimicrobial exposure and the risk of delirium in critically ill patients
Authors: Rashid Nadeem
Zainab Ameer Obeida
Sahish Kamat
Ahmed Nazir Elsousi
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Antibiotic
Cefepime
Published in: Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-019-2381-1

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Quality and quantity of sample size is crucial in clinical studies to exclude association: antimicrobial exposure and the risk of delirium in critically ill patients

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