Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Antibiotic | Review

Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia

Authors: Catia Cillóniz, Cristina Dominedò, Antoni Torres

Published in: Critical Care | Issue 1/2019

Login to get access

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://​www.​biomedcentral.​com/​collections/​annualupdate2019​. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://​www.​springer.​com/​series/​8901.
Literature
1.
Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27–72.CrossRef
2.
Aliberti S, Cilloniz C, Chalmers JD, et al. Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: a European perspective. Thorax. 2013;68:997–9.CrossRef
3.
Cillóniz C, Ewig S, Polverino E, et al. Microbial aetiology of community-acquired pneumonia and its relation to severity. Thorax. 2011;66:340–6.CrossRef
4.
Magiorakos A-P, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–81.CrossRef
5.
Versporten A, Zarb P, Caniaux I, et al. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. Lancet Glob Health. 2018;6:e619–29.CrossRef
6.
7.
Gellatly SL, Hancock REW. Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. Pathog Dis. 2013;67:159–73.CrossRef
8.
Crousilles A, Maunders E, Bartlett S, et al. Which microbial factors really are important in Pseudomonas aeruginosa infections? Future Microbiol. 2015;10:1825–36.CrossRef
9.
von Baum H, Welte T, Marre R, et al. Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: diagnosis, incidence and predictors. Eur Respir J. 2010;35:598–605.CrossRef
10.
Restrepo MI, Babu BL, Reyes LF, et al. Burden and risk factors for pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients. Eur Respir J. 2018;52:1709910.CrossRef
11.
Cillóniz C, Gabarrús A, Ferrer M, et al. Community-acquired pneumonia due to multidrug and non-multidrug resistant Pseudomonas aeruginosa. Chest. 2016;150:415–25.CrossRef
12.
Ferrer M, Travierso C, Cilloniz C, et al. Severe community-acquired pneumonia: characteristics and prognostic factors in ventilated and non-ventilated patients. PLoS One. 2018;13:e0191721.CrossRef
13.
Lim WS, Baudouin SV, George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax. 2009;64(Suppl 3):iii1–55.CrossRef
14.
15.
John TJ, Lalla U, Taljaard JJ, et al. An outbreak of community-acquired pseudomonas aeruginosa pneumonia in a setting of high water stress. QJM. 2017;110:855–6.CrossRef
16.
Cillóniz C, Civljak R, Nicolini A, Torres A. Polymicrobial community-acquired pneumonia: an emerging entity. Respirology. 2016;21:65–75.CrossRef
17.
18.
Eveillard M, Kempf M, Belmonte O, et al. Reservoirs of Acinetobacter baumannii outside the hospital and potential involvement in emerging human community-acquired infections. Int J Infect Dis. 2013;17:e802–5.CrossRef
19.
Wong D, Nielsen TB, Bonomo RA, et al. Clinical and pathophysiological overview of acinetobacter infections: a century of challenges. Clin Microbiol Rev. 2017;30:409–47.PubMed
20.
Dexter C, Murray GL, Paulsen IT, Peleg AY. Community-acquired Acinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis. Expert Rev Anti-Infect Ther. 2015;13:567–73.CrossRef
21.
Mody L, Foxman B, Bradley S, et al. Longitudinal assessment of multidrug-resistant organisms in newly admitted nursing facility patients: implications for an evolving population. Clin Infect Dis. 2018;67:837–44.CrossRef
22.
Peng C, Zong Z, Fan H. Acinetobacter baumannii isolates associated with community-acquired pneumonia in West China. Clin Microbiol Infect. 2012;18:E491–3.CrossRef
23.
Son YW, Jung IY, Ahn MY, et al. A case of community-acquired pneumonia caused by multidrug-resistant Acinetobacter baumannii in Korea. Infect Chemother. 2017;49:297–300.CrossRef
24.
Ong CWM, Lye DCB, Khoo KL, et al. Severe community-acquired Acinetobacter baumannii pneumonia: an emerging highly lethal infectious disease in the Asia-Pacific. Respirology. 2009;14:1200–5.CrossRef
25.
Kim YA, Kim JJ, Won DJ, Lee K. Seasonal and temperature-associated increase in community-onset Acinetobacter baumannii complex colonization or infection. Ann Lab Med. 2018;38:266–70.CrossRef
26.
Serota DP, Sexton ME, Kraft CS, Palacio F. Severe community-acquired pneumonia due to Acinetobacter baumannii in North America: case report and review of the literature. Open Forum Infect Dis. 2018;5:ofy044.PubMedPubMedCentral
27.
Eugenin EA. Community-acquired pneumonia infections by Acinetobacter baumannii: how does alcohol impact the antimicrobial functions of macrophages? Virulence. 2013;4:435–6.CrossRef
28.
Kamoshida G, Kikuchi-Ueda T, Nishida S, et al. Pathogenic bacterium Acinetobacter baumannii inhibits the formation of neutrophil extracellular traps by suppressing neutrophil adhesion. Front Immunol. 2018;9:178.CrossRef
29.
Anstey NM, Currie BJ, Hassell M, Palmer D, Dwyer B, Seifert H. Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups. J Clin Microbiol. 2002;40:685–6.CrossRef
30.
Peleg AY, Weerarathna T, McCarthy JS, Davis TME. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007;23:3–13.CrossRef
31.
Lee CR, Lee JH, Park KS, et al. Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms. Front Cell Infect Microbiol. 2017;7:483.CrossRef
32.
Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18:37–46.CrossRef
33.
Cano V, March C, Insua JL, et al. Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes. Cell Microbiol. 2015;17:1537–60.CrossRef
34.
Rafat C, Messika J, Barnaud G, et al. Hypervirulent Klebsiella pneumoniae, a 5-year study in a French ICU. J Med Microbiol. 2018;67:1083–9.CrossRef
35.
Rammaert B, Goyet S, Beauté J, et al. Klebsiella pneumoniae related community-acquired acute lower respiratory infections in Cambodia: clinical characteristics and treatment. BMC Infect Dis. 2012;12:3.CrossRef
36.
Ishida T, Ito A, Washio Y, et al. Risk factors for drug-resistant pathogens in immunocompetent patients with pneumonia: evaluation of PES pathogens. J Infect Chemother. 2017;23:23–8.CrossRef
37.
Lin YT, Jeng YY, Chen TL, Fung C-P. Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: clinical and microbiological characteristics in Taiwan, 2001-2008. BMC Infect Dis. 2010;10:307.CrossRef
38.
Tseng C-P, Wu H-S, Wu T-H, et al. Clinical characteristics and outcome of patients with community-onset Klebsiella pneumoniae bacteremia requiring intensive care. J Microbiol Immunol Infect. 2013;46:217–23.CrossRef
39.
Decré D, Verdet C, Emirian A, et al. Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France. J Clin Microbiol. 2011;49:3012–4.CrossRef
40.
Inghammar M, Borand L, Goyet S, et al. Community-acquired pneumonia and gram-negative bacilli in Cambodia-incidence, risk factors and clinical characteristics. Trans R Soc Trop Med Hyg. 2018;112:57–63.CrossRef
41.
Baker TM, Satlin MJ. The growing threat of multidrug-resistant gram-negative infections in patients with hematologic malignancies. Leuk Lymphoma. 2016;57:2245–58.CrossRef
42.
Brooke JS. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev. 2012;25:2–41.CrossRef
43.
Cha YK, Kim JS, Park SY, et al. Computed tomography findings of community-acquired Stenotrophomonas maltophilia pneumonia in an immunocompetent patient: a case report. Korean J Radiol. 2016;17:961–4.CrossRef
44.
45.
Mori M, Tsunemine H, Imada K, et al. Life-threatening hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in the treatment of hematologic diseases. Ann Hematol. 2014;93:901–11.CrossRef
46.
Falagas ME, Kastoris AC, Vouloumanou EK, Dimopoulos G. Community-acquired Stenotrophomonas maltophilia infections: a systematic review. Eur J Clin Microbiol Infect Dis. 2009;28:719–30.CrossRef
47.
Torres A, Lee N, Cilloniz C, et al. Laboratory diagnosis of pneumonia in the molecular age. Eur Respir J. 2016;48:1764–78.CrossRef
48.
Sibila O, Rodrigo-Troyano A, Shindo Y, et al. Multidrug-resistant pathogens in patients with pneumonia coming from the community. Curr Opin Pulm Med. 2016;22:219–26.CrossRef
49.
Gross AE, Van Schooneveld TC, Olsen KM, et al. Epidemiology and predictors of multidrug-resistant community-acquired and health care-associated pneumonia. Antimicrob Agents Chemother. 2014;58:5262–8.CrossRef
50.
Prina E, Ranzani OT, Polverino E, et al. Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia. Ann Am Thorac Soc. 2015;12:153–60.CrossRef
51.
Shindo Y, Ito R, Kobayashi D, et al. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2013;188:985–95.CrossRef
52.
Cao B, Huang Y, She DY, et al. Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese thoracic society, Chinese Medical Association. Clin Respir J. 2018;12:1320–60.CrossRef
53.
National Health and Medical Research Council. Therapeutic guidelines antibiotic version 15. In: Australian Clinical Practice Guidelines. Canberra: National Health and Medical Research Council; 2014.
Metadata
Title
Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia
Authors
Catia Cillóniz
Cristina Dominedò
Antoni Torres
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2371-3

Other articles of this Issue 1/2019

Critical Care 1/2019 Go to the issue

Research

Predicting mortality in patients undergoing VA-ECMO after coronary artery bypass grafting: the REMEMBER score

Research

Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study

Correction

Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis

Editorial

How I use Transcranial Doppler

Research

Impact of nutrition route on microaspiration in critically ill patients with shock: a planned ancillary study of the NUTRIREA-2 trial

Research

Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration