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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Acute Respiratory Distress-Syndrome | Letter

Angiotensin II in ECMO patients: a word of caution

Authors: Elio Antonucci, Fabio Silvio Taccone

Published in: Critical Care | Issue 1/2019

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Excerpt

We read with interest the recent letter by Ostermann et al. [1] about the administration of angiotensin II (Ang II) in patients treated by extracorporeal membrane oxygenation (ECMO). The authors reported seven patients with severe cardiorespiratory or respiratory failure receiving Ang II infusion during ECMO in the setting of high catecholamine doses. After Ang II initiation, they found a significant increase in blood pressure and a quick reduction in the need of other vasopressors. Despite the novelty of these findings, a word of caution should also be considered. …
Literature
1.
Ostermann M, Boldt DW, Harper MD, Lim GW, Gunnerson K. Angiotensin in ECMO patients with refractory shock. Crit Care. 2018;22(1):288.
2.
Khan A, Benthin C, Zeno B, Albertson TE, Boyd J, Christie JD. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Crit Care. 2017;21(1):234.
3.
Zambelli V, Bellani G, Borsa R, Pozzi F, Grassi A, Scanziani M, et al. Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental acute respiratory distress syndrome. Intensive Care Med Exp. 2015;3:44.PubMedCrossRef
4.
5.
Senchenkova EY, Russell J, Vital SA, Yildirim A, Orr AW, Granger DN. A critical role for both CD40 and VLA5 in angiotensin II-mediated thrombosis and inflammation. FASEB J. 2018;32:3448–56.PubMedCrossRef
6.
Orfanos SE, Armaganidis A, Glynos C et al. Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injury. Circulation. 2000;102(16):2011–8.PubMedCrossRef
7.
Busse LW, McCurdy MT, Ali O, Hall A, Chen H, Ostermann M. The effect of angiotensin II on blood pressure in patients with circulatory shock: a structured review of the literature. Crit Care. 2017;21(1):324.
8.
Chawla LS, Chen S, Bellomo R, Tidmarsh GF. Angiotensin converting enzyme defects in shock: implications for future therapy. Crit Care 2018;22(1):274.
Metadata
Title
Angiotensin II in ECMO patients: a word of caution
Authors
Elio Antonucci
Fabio Silvio Taccone
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2337-5

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