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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Commentary

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Author: Jing Li

Published in: Critical Care | Issue 1/2018

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Abstract

Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Pooled analyses demonstrated a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C.
Literature
1.
Sheikh M, Horner D. Bet 2: does intravenous vitamin C improve mortality in patients with severe sepsis? Emerg Med J. 2018;35(4):272–4.CrossRef
2.
Teng J, Pourmand A, Mazer-Amirshahi M. Vitamin C: the next step in sepsis management? J Crit Care. 2018;43:230–4.CrossRef
3.
Fowler AA 3rd, Syed AA, Knowlson S, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12:32.CrossRef
4.
Natarajan R, Fisher BJ, Syed AA, et al. Impact of intravenous ascorbic acid infusion on novel biomarkers in patients with severe sepsis. J Pulm Respir Med. 2014;4(6):2.CrossRef
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Tanaka H, Matsuda T, Miyagantani Y, et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg. 2000;135(3):326–31.CrossRef
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Zabet MH, Mohammadi M, Ramezani M, et al. Effect of high-dose ascorbic acid on vasopressor's requirement in septic shock. J Res Pharm Pract. 2016;5(2):94–100.CrossRef
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Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, vitamin C, and thiamine or the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017;151(6):1229–38.CrossRef
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Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5(1):13.CrossRef
Metadata
Title
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Author
Jing Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2191-x

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