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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Viewpoint

The role of bile acids in nutritional support

Authors: Gustav van Niekerk, Tanja Davis, Willem de Villiers, Anna-Mart Engelbrecht

Published in: Critical Care | Issue 1/2018

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Abstract

Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there remains much controversy regarding the clinical efficacy of such interventions. In addition to the direct effect of nutrition in terms of micro- and macronutrient content, nutritional formulations may exert an effect via the physiological response to feeding. Here, we highlight the key role of postprandial reabsorbed bile acids in attenuating both the inflammatory response and autophagy. These observations suggest that not all patients would benefit from aggressive nutritional support.
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Metadata
Title
The role of bile acids in nutritional support
Authors
Gustav van Niekerk
Tanja Davis
Willem de Villiers
Anna-Mart Engelbrecht
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2160-4

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