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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Letter

Predicting the requirement for renal replacement therapy in intensive care patients with sepsis

Authors: Axel Nierhaus, Frank Bloos, Darius Cameron Wilson, Gunnar Elke, Patrick Meybohm, the SepNet Critical Care Trials Group

Published in: Critical Care | Issue 1/2018

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Excerpt

Sepsis is one of the most frequent causes of acute kidney injury (AKI) in critically ill patients, with initial organ impairment often followed by dysfunction in other systems [1]. Renal dysfunction may therefore represent one facet in the evolution towards multiple organ dysfunction syndrome (MODS) or, alternatively, may be indicative of system-wide endothelial damage caused by hyperinflammation and a positive fluid balance. Whilst numerous biomarkers have been investigated to predict renal replacement therapy (RRT) requirement, including NGAL, TIMP-2 and IGFBP-7 [2], mid-regional proadrenomedullin (MR-proADM) may also be of interest due to its involvement in capillary leakage, endothelial dysfunction and the initial stages of multiple organ failure development [3, 4]. …
Literature
1.
Ziesmann MT, Marshall JC. Multiple organ dysfunction: the defining syndrome of sepsis. Surg Infect. 2018;19(2):184–90.CrossRef
2.
Klein SJ, Brandtner AK, Lehner GF, et al. Biomarkers for prediction of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis. Intensive Care Med. 2018;44(3):323–36.CrossRefPubMedPubMedCentral
3.
Elke G, Bloos F, Wilson DC, et al. The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis--a secondary analysis of a large randomised controlled trial. Crit Care. 2018;22(1):79.CrossRefPubMedPubMedCentral
4.
Elke G, Bloos F, Wilson DC, Meybohm P. Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores. Crit Care. 2018;22(1):147.CrossRefPubMedPubMedCentral
5.
Bloos F, Trips E, Nierhaus A. Effect of sodium selenite administration and procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: a randomized clinical trial. JAMA Intern Med. 2016;176(9):1266–76.CrossRefPubMed
Metadata
Title
Predicting the requirement for renal replacement therapy in intensive care patients with sepsis
Authors
Axel Nierhaus
Frank Bloos
Darius Cameron Wilson
Gunnar Elke
Patrick Meybohm
the SepNet Critical Care Trials Group
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2135-5

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