Skip to main content
Top
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Commentary

Sepsis is a preventable public health problem

Authors: Jordan A. Kempker, Henry E. Wang, Greg S. Martin

Published in: Critical Care | Issue 1/2018

Login to get access

Abstract

There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework for sepsis as a public health problem by adapting the traditional model of primary, secondary, and tertiary prevention.
Literature
3.
go back to reference Wang HE, Donnelly JP, Griffin R, Levitan EB, Shapiro NI, Howard G, Safford MM. Derivation of novel risk prediction scores for community-acquired sepsis and severe sepsis. Crit Care Med. 2016;44:1285–94.CrossRefPubMedPubMedCentral Wang HE, Donnelly JP, Griffin R, Levitan EB, Shapiro NI, Howard G, Safford MM. Derivation of novel risk prediction scores for community-acquired sepsis and severe sepsis. Crit Care Med. 2016;44:1285–94.CrossRefPubMedPubMedCentral
4.
go back to reference Kempker JA, Magee MJ, Cegielski JP, Martin GS. Associations between vitamin D level and hospitalizations with and without an infection in a national cohort of medicare beneficiaries. Am J Epidemiol. 2016;183:920–9.CrossRefPubMedPubMedCentral Kempker JA, Magee MJ, Cegielski JP, Martin GS. Associations between vitamin D level and hospitalizations with and without an infection in a national cohort of medicare beneficiaries. Am J Epidemiol. 2016;183:920–9.CrossRefPubMedPubMedCentral
5.
go back to reference Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–54.CrossRefPubMed Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–54.CrossRefPubMed
6.
go back to reference Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589–96.CrossRefPubMed Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589–96.CrossRefPubMed
7.
go back to reference Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, Lemeshow S, Osborn T, Terry KM, Levy MM. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376:2235–44.CrossRefPubMedPubMedCentral Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, Lemeshow S, Osborn T, Terry KM, Levy MM. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376:2235–44.CrossRefPubMedPubMedCentral
9.
go back to reference Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP, Intermountain Healthcare Intensive Medicine Clinical Program. Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med. 2013;188:77–82.CrossRefPubMedPubMedCentral Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP, Intermountain Healthcare Intensive Medicine Clinical Program. Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med. 2013;188:77–82.CrossRefPubMedPubMedCentral
10.
go back to reference Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36:222–31.CrossRefPubMedPubMedCentral Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36:222–31.CrossRefPubMedPubMedCentral
13.
14.
go back to reference Wang HE, Moore JX, Donnelly JP, Levitan EB, Safford MM. Risk of acute coronary heart disease after sepsis hospitalization in the REasons for Geographic and Racial Differences in Stroke cohort. Clin Infect Dis. 2017;65:29–36.CrossRefPubMedPubMedCentral Wang HE, Moore JX, Donnelly JP, Levitan EB, Safford MM. Risk of acute coronary heart disease after sepsis hospitalization in the REasons for Geographic and Racial Differences in Stroke cohort. Clin Infect Dis. 2017;65:29–36.CrossRefPubMedPubMedCentral
Metadata
Title
Sepsis is a preventable public health problem
Authors
Jordan A. Kempker
Henry E. Wang
Greg S. Martin
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2048-3

Other articles of this Issue 1/2018

Critical Care 1/2018 Go to the issue