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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Viewpoint

The curse of angiopoietin-2 in ARDS: on stranger TI(E)des

Authors: Philipp Kümpers, Alexander Lukasz

Published in: Critical Care | Issue 1/2018

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Abstract

Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.
Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins.
This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.
Footnotes
1
Pirates of the Caribbean: on stranger tides is a fantasy swashbuckler film produced by Walt Disney Pictures and released in the USA on 20 May 2011.
 
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Metadata
Title
The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
Authors
Philipp Kümpers
Alexander Lukasz
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-1978-0

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