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Critical Care
Published in: Critical Care 1/2017

Open Access 01-12-2017 | Viewpoint

Complications of regional citrate anticoagulation: accumulation or overload?

Authors: Antoine G. Schneider, Didier Journois, Thomas Rimmelé

Published in: Critical Care | Issue 1/2017

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Abstract

Regional citrate anticoagulation (RCA) is now recommended over systemic heparin for continuous renal replacement therapy in patients without contraindications. Its use is likely to increase throughout the world. However, in the absence of citrate blood level monitoring, the diagnosis of citrate accumulation, the most feared complication of RCA, remains relatively complex. It is therefore commonly mistaken with other conditions. This review aims at providing clarifications on RCA-associated acid-base disturbances and their management at the bedside. In particular, the authors wish to propose a clear distinction between citrate accumulation and net citrate overload.
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Metadata
Title
Complications of regional citrate anticoagulation: accumulation or overload?
Authors
Antoine G. Schneider
Didier Journois
Thomas Rimmelé
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1880-1

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