Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Letter

Coughing correlates: insights into an innovative study using cough peak expiratory flow to predict extubation failure

Authors: Chuan Jiang, Antonio M. Esquinas, Bushra Mina

Published in: Critical Care | Issue 1/2016

Login to get access

Excerpt

We read the innovative study by Duan et al. [1] with great interest. However, key results need to be interpreted carefully to reach the proper conclusions. First, their primary finding that patients with low cough peak expiratory flow (CPEF) have significant benefit from non-invasive positive pressure ventilation (NIPPV) in the prevention of re-intubation and 90-day mortality is not unsurprising given how CPEF represents the severity of underlying respiratory pathology. In addition, the strength of their study lay in the methodology. Each precise detail regarding the protocol of weaning and re-intubation mirrors that of previous landmark studies [2, 3]. These careful design choices help to bridge the methodological differences and heterogeneity among preceding studies. …
Literature
1.
2.
Keenan SP, Powers C, McCormack DG, Block G. Nonivnasive positive-pressure ventilation for postextubation respiratory distress: a randomized controlle trial. JAMA. 2002;287:3238–44.CrossRefPubMed
3.
Ferrer M, Sellares J, Valencia M, Carrillo A, Gonzalez G, Badia JR, Nicolas JM, Torres A. Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders: randomized controlled trial. Lancet. 2009;374(9695):1082–8.CrossRefPubMed
4.
Beuret P, Roux C, Auclair A, Nourdine K, Kaaki M, Carton MJ. Interest of an objective evaluation of cough during weaning from mechanical ventilation. Intensive Care Med. 2009;35(6):1090.CrossRefPubMed
5.
Salam A, Tilluckdharry L, Amoateng-Adjepong Y, Manthous CA. Neurologic status, cough, secretions, and extubation outcomes. Intensive Care Med. 2004;30(7):1334.CrossRefPubMed
Metadata
Title
Coughing correlates: insights into an innovative study using cough peak expiratory flow to predict extubation failure
Authors
Chuan Jiang
Antonio M. Esquinas
Bushra Mina
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1574-0

Other articles of this Issue 1/2016

Critical Care 1/2016 Go to the issue

Letter

Work of breathing, not dysoxia, as the cause of low central venous blood O2 saturation in sepsis

Commentary

Saline versus balanced solutions: are clinical trials comparing two crystalloid solutions really needed?

Review

Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE

Research

Prognostic impact of restored sinus rhythm in patients with sepsis and new-onset atrial fibrillation

Review

The role of neutrophils in immune dysfunction during severe inflammation

Research

Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study