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Open Access 01-12-2016 | Letter

Not all β-lactams are equal regarding neurotoxicity

Authors: Khalil Chaïbi, Maïté Chaussard, Sabri Soussi, Matthieu Lafaurie, Matthieu Legrand

Published in: Critical Care | Issue 1/2016

Excerpt

We read with interest the letter from May et al. recently published in Critical Care [1]. The authors suggest that overdosing of β-lactams in 108 critically ill patients receiving renal replacement therapy may not be associated with neurotoxicity. We agree that adequate plasmatic levels of β-lactams in critically ill patients with sepsis should be a primary goal and that under-dosing may put the patient at a dangerous risk of treatment failure [2]. We are, however, concerned about the conclusions of this letter and would like to comment on two points. …

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Honore PM, Spapen HD. Cefepime-induced neurotoxicity in critically ill patients undergoing continuous renal replacement therapy: beware of dose reduction! Crit Care. 2015;19:455.CrossRefPubMedPubMedCentral

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Title: Not all β-lactams are equal regarding neurotoxicity
Authors: Khalil Chaïbi
Maïté Chaussard
Sabri Soussi
Matthieu Lafaurie
Matthieu Legrand
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-016-1522-z

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